Retinal metastasis regression with eribulin in a heavily pretreated breast cancer patient

被引：3

作者：

Gubbiotti, Marta ^{[1
]}

Pistilli, Barbara ^{[2
]}

Tudini, Marianna ^{[3
]}

Benedetti, Giovanni ^{[2
]}

Galizia, Eva ^{[4
]}

Rusiello, Marco ^{[2
]}

Latini, Luciano ^{[2
]}

机构：

[1] Univ Perugia, S Maria Hosp, Oncohematol Unit, Terni, Italy

[2] Macerata Hosp, Oncol Unit, Macerata, Italy

[3] Univ Aquila, San Salvatore Hosp, Med Oncol Unit, I-67100 Laquila, Italy

[4] Univ Politecn Marche, AO Osped Riuniti, Med Oncol Unit, Ancona, Italy

来源：

FUTURE ONCOLOGY | 2015年 / 11卷 / 15期

关键词：

brain metastases; breast cancer; eribulin; retinal metastases; HALICHONDRIN B ANALOG; PHASE-II; BRAIN METASTASES; 1ST-LINE THERAPY; OPEN-LABEL; MESYLATE; MULTICENTER; ANTHRACYCLINE; TRASTUZUMAB; BIOPSY;

D O I：

10.2217/fon.15.148

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The authors present the case of a heavily pretreated young woman with retinal and brain metastases from breast cancer who was successfully treated with eribulin. Eribulin was given at 1.1 mg/m(2) on day 1 and 8, every 3 weeks for a total of 12 courses. A significant reduction in the size of brain and retinal lesions was achieved after three cycles. The treatment was continued for 12 cycles, with a good profile of tolerability. In this clinical case, eribulin demonstrated to be active on brain and retinal metastases from breast cancer, although preclinical data showed limited ability to cross the blood-brain barrier.

引用

页码：17 / 22

页数：6

共 21 条

[1] Biopsy in indeterminate intraocular tumors [J].

Bechrakis, NE ;

Foerster, MH ;

Bornfeld, N .

OPHTHALMOLOGY, 2002, 109 (02) :235-242

[2] Retinal tumors in adults: diagnosis and management [J].

Bechrakis, Nikolaos E. ;

Kreusel, Klaus-Martin .

EXPERT REVIEW OF OPHTHALMOLOGY, 2011, 6 (03) :347-361

[3]

BLOCH RS, 1971, ARCH OPHTHALMOL-CHIC, V85, P673

[4] Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: Multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm [J].

Burstein, HJ ;

Harris, LN ;

Marcom, PK ;

Lambert-Falls, R ;

Havlin, K ;

Overmoyer, B ;

Friedlander, RJ ;

Gargiulo, J ;

Strenger, R ;

Vogel, CL ;

Ryan, PD ;

Ellis, MJ ;

Nunes, RA ;

Bunnell, CA ;

Campos, SM ;

Hallor, M ;

Gelman, R ;

Winer, EP .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (15) :2889-2895

[5] Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study [J].

Cortes, Javier ;

O'Shaughnessy, Joyce ;

Loesch, David ;

Blum, Joanne L. ;

Vahdat, Linda T. ;

Petrakova, Katarina ;

Chollet, Philippe ;

Manikas, Alexey ;

Dieras, Veronique ;

Delozier, Thierry ;

Vladimirov, Vladimir ;

Cardoso, Fatima ;

Koh, Han ;

Bougnoux, Philippe ;

Dutcus, Corina E. ;

Seegobin, Seth ;

Mir, Denis ;

Meneses, Nicole ;

Wanders, Jantien ;

Twelves, Chris .

LANCET, 2011, 377 (9769) :914-923

[6] Phase II Study of the Halichondrin B Analog Eribulin Mesylate in Patients With Locally Advanced or Metastatic Breast Cancer Previously Treated With an Anthracycline, a Taxane, and Capecitabine [J].

Cortes, Javier ;

Vahdat, Linda ;

Blum, Joanne L. ;

Twelves, Chris ;

Campone, Mario ;

Roche, Henri ;

Bachelot, Thomas ;

Awada, Ahmad ;

Paridaens, Robert ;

Goncalves, Anthony ;

Shuster, Dale E. ;

Wanders, Jantien ;

Fang, Fang ;

Gurnani, Renuka ;

Richmond, Elaine ;

Cole, Patricia E. ;

Ashworth, Simon ;

Allison, Mary Ann .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (25) :3922-3928

[7] Survival in patients with brain metastases from breast cancer [J].

Eichler, April F. ;

Kuter, Irene ;

Ryan, Paula ;

Schapira, Lidia ;

Younger, Jerry ;

Henson, John W. .

CANCER, 2008, 112 (11) :2359-2367

[8] Fine needle aspiration biopsy in selecting treatment for inconclusive intraocular disease [J].

Eide, N ;

Syrdalen, P ;

Walaas, L ;

Hagmar, B .

ACTA OPHTHALMOLOGICA SCANDINAVICA, 1999, 77 (04) :448-452

[9] The blood-brain barrier/neurovascular unit in health and disease [J].

Hawkins, BT ;

Davis, TP .

PHARMACOLOGICAL REVIEWS, 2005, 57 (02) :173-185

[10] A Phase Ill, open-label, randomized, multicenter study of eribulin mesylate versus capecitabine in patients with locally advanced or metastatic breast cancer previously treated with anthracyclines and taxanes [J].

Kaufman, P. A. ;

Awada, A. ;

Twelves, C. ;

Yelle, L. ;

Perez, E. A. ;

Wanders, J. ;

Olivo, M. S. ;

He, Y. ;

Dutcus, C. E. .

CANCER RESEARCH, 2012, 72

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