Mononuclear metal complexes with Piroxicam:: Synthesis, structure and biological activity

被引：82
作者：
Christofis, P
Katsarou, M
Papakyriakou, A
Sanakis, Y
Katsaros, N
Psomas, G [1 ]
机构：
[1] NCSR Demokritos, Inst Phys Chem, GR-15310 Athens, Greece
[2] NCSR Demokritos, Inst Mat Sci, GR-15310 Athens, Greece
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2005年 / 99卷 / 11期
关键词：
Piroxicam complexes; apoptosis; cytotoxicity; spectroscopic study; molecular modeling;
D O I：
10.1016/j.jinorgbio.2005.07.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Piroxicam (= Hpir) is a non-steroidal anti-inflammatory and an anti-arthritic drug. VO2+, Mn2+, Fe3+, MoO22+ and UO22+ complexes with deprotonated piroxicam have been prepared and characterized with the use of infrared, UV-Vis, nuclear magnetic resonance and electron paramagnetic resonance spectroscopies. The experimental data suggest that piroxicam acts as a deprotonated bidentate ligand in all complexes and is coordinated to the metal ion through the pyridine nitrogen and the amide oxygen. Molecular mechanics calculations in the gas state have been performed in order to propose a model for the Fe3+, VO2+ and MoO22+ complexes. Potential anticancer cytostatic and cytotoxic effects of piroxicam complexes with VO2+, Mn2+ and MoO22+ on human promyelocytic leukemia HL-60 cells have been investigated. Among all complexes, only VO(pir)(2)(H2O) clearly induces apoptosis after 24-h incubation, whereas piroxicam induces apoptosis after 57-h incubation. (c) 2005 Elsevier Inc. All rights reserved.
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收藏
页码：2197 / 2210
页数：14
相关论文
共 125 条
[1]   Spectroscopic characterization of some tetradentate Schiff bases and their complexes with nickel, copper and zinc [J].
Abd-Elzaher, MM .
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2001, 48 (02) :153-158
[2]   CONFORMATIONAL-ANALYSIS .130. MM2 - HYDROCARBON FORCE-FIELD UTILIZING V1 AND V2 TORSIONAL TERMS [J].
ALLINGER, NL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (25) :8127-8134
[3]   THE MODE OF ACTION OF ASPIRIN-LIKE DRUGS - EFFECT ON INDUCIBLE NITRIC-OXIDE SYNTHASE [J].
AMIN, AR ;
VYAS, P ;
ATTUR, M ;
LESZCZYNSKAPIZIAK, J ;
PATEL, IR ;
WEISSMANN, G ;
ABRAMSON, SB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) :7926-7930
[4]  
ANDO GA, 1983, EUR J RHEUMATOL INFL, V6, P3
[5]   Synthesis, characterization and catalytic activity of addition compounds of dioxomolybdenum(VI) pyridine-2,6-dicarboxylate.: Crystal structure of MoO2(dipic)(L) (L = DMF, DMSO, OPPh3) [J].
Arnáiz, FJ ;
Aguado, R ;
Pedrosa, MR ;
De Cian, A ;
Fischer, J .
POLYHEDRON, 2000, 19 (20-21) :2141-2147
[6]  
BAGNALL KW, 1989, COMPREHENSIVE COORDI, V3, P1129
[7]   The Electronic Structure of the Vanadyl Ion [J].
Ballhausen, C. J. ;
Gray, Harry B. .
INORGANIC CHEMISTRY, 1962, 1 (01) :111-122
[8]   Oxovanadium(IV) and oxovanadium(V) complexes relevant to biological systems [J].
Baran, EJ .
JOURNAL OF INORGANIC BIOCHEMISTRY, 2000, 80 (1-2) :1-10
[9]   THE PREPARATION AND CRYSTAL-STRUCTURES OF NEW PLATINUM PHOSPHONATE COMPLEXES [J].
BAU, R ;
HUANG, SKS ;
FENG, JA ;
MCKENNA, CE .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (22) :7546-7547
[10]   STUDIES ON THE MECHANISM BY WHICH INDOMETHACIN INCREASES THE ANTICANCER EFFECT OF METHOTREXATE [J].
BENNETT, A ;
GAFFEN, JD ;
MELHUISH, PB ;
STAMFORD, IF .
BRITISH JOURNAL OF PHARMACOLOGY, 1987, 91 (01) :229-235
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