Hypertriglyceridaemic insulin-resistant obese dog model: effects of high-fat diet depending on age

被引:11
作者
Serisier, S. [1 ,2 ]
Gayet, C. [1 ]
Leray, V. [1 ]
Le Bloc'h, J. [1 ,2 ]
Ouguerram, K. [2 ]
Magot, T. [2 ]
Nguyen, P. [1 ]
机构
[1] Natl Vet Sch Nantes, Endocrinol & Nutr Unit, F-44307 Nantes 3, France
[2] Univ Hosp, INSERM, U539, Nantes, France
关键词
obese dog; insulin resistance; high-fat diet; age;
D O I
10.1111/j.1439-0396.2007.00785.x
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
In humans, obesity is closely associated with insulin resistance (IR) and dyslipidaemia. The purpose of this study was to explore the effect of age on metabolic disturbances related to obesity in dogs (n = 25). Three age-groups of dogs (puppies, young adults and mature adults) were overfed to induce obesity, and body composition, insulin sensitivity index (I-IS) (euglycaemic-hyperinsulinaemic glucose clamp) and plasma lipids were measured. Fat mass was similar in the three obese groups (30 +/- 1% in puppies, 34 +/- 1% in young adults and 39 +/- 1% in mature adults). In mature adults, body weight (BW) increased (+45%, p < 0.001) and I-IS decreased (-60%, p < 0.001) over 22 weeks. In young adults, BW gain was similar but slower (60 weeks) and I-IS decreased to a lesser extent (-49%, p < 0.001). Overfed puppies weighed 30% more (p < 0.01) than normally-fed control puppies, but there was no change in I-IS. Unlike young and mature adults, obese puppies did not exhibit significant changes in triglycerides (TG) and free fatty acid concentrations. In conclusion, as in humans, obese dogs develop IR that is associated with high TG levels; however, younger animals may be better able to balance energy needs with energy consumption.
引用
收藏
页码:419 / 425
页数:7
相关论文
共 36 条
  • [1] ASHWELL M, 1987, INT J OBESITY, V11, P357
  • [2] An insulin-resistant hypertriglyceridaemic normotensive obese dog model: assessment of insulin resistance by the euglycaemic hyperinsulinaemic clamp in combination with the stable isotope technique
    Bailhache, E
    Ouguerram, K
    Gayet, C
    Krempf, M
    Siliart, B
    Magot, T
    Nguyen, P
    [J]. JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION, 2003, 87 (3-4) : 86 - 95
  • [3] Lipoproteins abnormalities in obese insulin-resistant dogs
    Bailhache, E
    Nguyen, P
    Krempf, M
    Siliart, B
    Magot, T
    Ouguerram, K
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2003, 52 (05): : 559 - 564
  • [4] BASSO L V, 1970, Journal of Clinical Investigation, V49, P537, DOI 10.1172/JCI106264
  • [5] THE INSULIN SENSITIVITY INDEX IN NONDIABETIC MAN - CORRELATION BETWEEN CLAMP-DERIVED AND IVGTT-DERIVED VALUES
    BEARD, JC
    BERGMAN, RN
    WARD, WK
    PORTE, D
    [J]. DIABETES, 1986, 35 (03) : 362 - 369
  • [6] Effect of dietary fat on whole body fatty acid synthesis in weanling rats
    Brooks, SPJ
    Lampi, BJ
    [J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 1999, 10 (05) : 291 - 298
  • [7] Uncoupling protein-3 gene expression in skeletal muscle during development is regulated by nutritional factors that alter circulating non-esterified fatty acids
    Brun, S
    Carmona, MC
    Mampel, T
    Viñas, O
    Giralt, M
    Iglesias, R
    Villarroya, F
    [J]. FEBS LETTERS, 1999, 453 (1-2): : 205 - 209
  • [8] Capeau A, 2005, M S-MED SCI, V21, P34
  • [9] EFFECTS OF FASTING AND REFEEDING ON THE LEVEL OF UNCOUPLING PROTEIN MESSENGER-RNA IN RAT BROWN ADIPOSE-TISSUE - EVIDENCE FOR DIET-INDUCED AND COLD-INDUCED RESPONSES
    CHAMPIGNY, O
    RICQUIER, D
    [J]. JOURNAL OF NUTRITION, 1990, 120 (12) : 1730 - 1736
  • [10] Genetics and pathophysiology of human obesity
    Cummings, DE
    Schwartz, MW
    [J]. ANNUAL REVIEW OF MEDICINE, 2003, 54 : 453 - 471