Quantitative myelin-related maps from R1 and T2*ratio images using a single ME-MP2RAGE sequence in 7T MRI

被引：6

作者：

Shim, Jeong-Min ^{[1
]}

Cho, Seo-Eun ^{[2
]}

Kang, Seung-Gul ^{[2
]}

Kang, Chang-Ki ^{[1
,3
]}

机构：

[1] Gachon Univ, Neurosci Res Inst, Incheon, South Korea

[2] Gachon Univ, Gil Med Ctr, Coll Med, Dept Psychiat, Incheon, South Korea

[3] Gachon Univ, Coll Hlth Sci, Dept Radiol Sci, Incheon, South Korea

来源：

FRONTIERS IN NEUROANATOMY | 2022年 / 16卷

基金：

新加坡国家研究基金会;

关键词：

myelin-related map; relaxation times; ratio mapping; ME-MP2RAGE; 7T MRI; WHITE-MATTER; IRON CONCENTRATION; BRAIN; DEMYELINATION; ORIENTATION; MARKER; AREAS;

D O I：

10.3389/fnana.2022.950650

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Background: There still are limitations associated with quantifying myelin content using brain magnetic resonance imaging (MRI) despite several studies conducted on this subject. Therefore, this study aimed: (1) to propose a myelin-related mapping technique to obtain the quantitative R1/T2* (q-Ratio) that has the advantage of quick processing and less dependency on imaging parameters, (2) to validate this adapted q-Ratio method by comparing the quantitative myelin-related map with those acquired through an existing mapping method [T1-weighted/T2*-weighted (w-Ratio)], and (3) to determine the q-Ratio myelin-related values in the white and gray matter, and the relationship between the q-Ratio myelin-related value and cerebral volume size in regions of interest (ROIs) in a healthy population.Methods: The multi-echo magnetization-prepared 2 rapid gradient echoes (ME-MP2RAGE) sequence was used in a 7 Tesla (7T) MRI for the acquisition of data regarding myelin content in 10 healthy participants. A correlation analysis was performed between myelin-related values obtained through the q-Ratio and w-Ratio methods. Additionally, myelin distribution was analyzed and compared in the white and gray matter, and the correlation between cerebral volume size and q-Ratio myelin-related value was analyzed in ROIs in the brain.Results: The myelin-related maps acquired through the q-Ratio and w-Ratio methods were significantly correlated (p < 0.001), but the q-Ratio myelin-related map was much clearer. Additionally, the cerebral volume size in the gray matter was 399.40% larger than that in the white matter, but the q-Ratio myelin-related value in the gray matter was 80.83% lower than that of the white matter. Furthermore, volume size was positively correlated with q-Ratio myelin-related values in the white matter (r = 0.509, p = 0.006) but not in the gray matter (r = -0.133, p = 0.402).Conclusions: In this study, we validated using a q-Ratio myelin-related map that was acquired in one imaging sequence at 7T MRI. In addition, we found a significant correlation between ROI volume size and the q-Ratio myelin-related value in the white matter but not in the gray matter. It is expected that this technique could be applied to the study of various neuropsychiatric diseases related to demyelination in the future.

引用

页数：11

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