Antigene property of PNA conjugated to the nuclear localization signal peptide

被引：14
作者：
Cogoi, S [1 ]
Codognotto, A [1 ]
Rapozzi, V [1 ]
Xodo, LE [1 ]
机构：
[1] Sch Med, Dept Biochem Sci & Technol, I-33100 Udine, Italy
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2005年 / 24卷 / 5-7期
关键词：
NLS-conjugated PNA; mutated K-ras gene; antigene activity; pancreatic cells;
D O I：
10.1081/NCN-200059333
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Peptide nucleic acid (PNA) is a DNA mimic with antigene properties. To enhance its capacity to enter in the cell and internalize in the nucleus, PNA has been conjugated to the nuclear localization signal (NLS) peptide, PKKKRKV. PNA-NLS conjugates form stable hybrids with complementary DNA strands and poorly tolerate mismatched base pairing. Employed against cancer-associated genes, PNA-NLS exhibited a potent and specific antigene activity, suggesting exciting therapeutic approaches to cancer.
引用
收藏
页码：971 / 974
页数：4
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