Characterization of interaction between gatifloxacin and bovine serum albumin

被引：4
作者：
Guo, M
Yan, JW
Yu, QS [1 ]
Shang, ZC
Lü, JD
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China
[2] Zhejiang Univ, Dept Chinese Med Sci & Engn, Hangzhou 310027, Peoples R China
来源：
ACTA PHYSICO-CHIMICA SINICA | 2004年 / 20卷 / 02期
关键词：
gatifloxacin; bovine serum albumin(BSA); capillary electrophoresis; non-linear fitting;
D O I：
10.3866/PKU.WHXB20040220
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The present study describes the application of capillary zone electrophoresis(CZE) to investigate the interaction between bovine serum albumin and gatifloxacin, the simplified method of Hummel-Dreyer was applied and the experimental condition was established after a large number of tests. Based on the site-binding model, practical formula for small ligand molecule to bio-macromolecule has been proposed, the binding parameters were measured according to suggested model by non-linear fitting program.
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收藏
页码：202 / 206
页数：5
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