Fertility counseling in women with hereditary cancer syndromes

被引:10
作者
Somigliana, Edgardo [1 ,2 ]
Costantini, Maria Paola [3 ]
Filippi, Francesca [1 ]
Terenziani, Monica [4 ]
Riccaboni, Alessandra [1 ]
Nicotra, Valeria [5 ]
Rago, Rocco [6 ]
Paffoni, Alessio [7 ]
Mencaglia, Luca [8 ]
Magnolfi, Stefania [8 ]
Zuccarello, Daniela [9 ]
Rienzi, Laura [10 ]
Spinella, Francesca [11 ]
Capalbo, Antonio [12 ]
Scaravelli, Giulia [13 ]
Testa, Salvo [14 ]
机构
[1] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Infertil Unit, Via M Fanti 6, I-20122 Milan, Italy
[2] Univ Milan, Dept Clin Sci & Commun Hlth, Milan, Italy
[3] Legal Counsultor Hlth Human Rights Law Firm, Rome, Italy
[4] Fdn IRCCS, Ist Nazl Tumori, Pediat Oncol Unit, Milan, Italy
[5] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Unit Med Genet, Milan, Italy
[6] Sandro Pertini Hosp, Physiopathol Reprod & Androl Unit, Rome, Italy
[7] Azienda Socio Sanitaria Territoriale Lariana, Infertil Unit, Cantu, Italy
[8] Santa Margherita Hosp, ART Ctr, Cortona, Italy
[9] Univ Hosp Padova, Dept Lab Med, Epidemiol & PGT Unit, Unit Clin Genet, Padua, Italy
[10] GeneraLife IVF Ctrs, Clin Valle Giulia, Rome, Italy
[11] Eurofins Genoma Grp, Mol Genet Labs, Rome, Italy
[12] Igenomix, Marostica, Italy
[13] Natl Ctr Dis Prevent & Hlth Promot, ART Italian Natl Register, NIH, Rome, Italy
[14] Mutagens, Nonprofit Org, Milan, Italy
关键词
Hereditary cancer syndrome; Fertility preservation; Oocytes cryopreservation; Preimplantation genetic diagnosis; Oocytes donation; OVARIAN-CANCER; PGD; PRESERVATION; FOLLOW;
D O I
10.1016/j.critrevonc.2022.103604
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hereditary cancer syndromes are a heterogeneous group of genetic conditions that are associated with an increased risk of developing cancer during lifespan. In affected women, parenthood may be accompanied by concerns for the offspring, considering the common autosomal dominant inheritance. Moreover, fertility preservation to prevent the detrimental effects of cancer treatments differs compared to other clinical contexts. The necessity to preserve gametes is indeed predictable and expected to be common. For these reasons, we advocate a personalized and early fertility counseling. Carriers should be aware of the risk of transmission. The possibility to perform elective oocytes cryopreservation, either before (previvors) or after (survivors) cancer diagnosis should be discussed. Finally, they should be informed about the options of preimplantation genetic test (PGT) and oocytes donation. In conclusion, physicians engaged in oncofertility should personalize the counseling for women with hereditary cancer syndromes, being aware of their peculiar needs.
引用
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页数:6
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