Synthesis of double C-glycoside analogue of sTn

被引：16
作者：
Ress, DK
Baytas, SN
Wang, Q
Muñoz, EM
Tokuzoki, K
Tomiyama, H
Linhardt, RJ [1 ]
机构：
[1] Univ Iowa, Div Med & Nat Prod Chem, Iowa City, IA 52242 USA
[2] Kotobuki Pharmaceut Co Ltd, Nagano, Japan
[3] Rensselaer Polytech Inst, Dept Biol, Troy, NY 12180 USA
[4] Rensselaer Polytech Inst, Dept Biol & Chem Engn, Troy, NY 12180 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 20期
关键词：
D O I：
10.1021/jo050691n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A sTn double C-glycoside, sTn analogue 2, was synthesized using samarium chemistry developed in our laboratory. Complications in the oxidation reaction affording aldehyde acceptor were overcome by double protection of amide and the use of a room-temperature ionic liquid as solvent. Studies are underway to conjugate the sTn double C-glycoside hapten 2 to KLH carrier protein for biological evaluation as a vaccine.
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收藏
页码：8197 / 8200
页数：4
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