The metabolic adaptation of the adult offspring after maternal high-dosed folic acid supplementation based on the proteomics and metabolomics in rats

被引：0
作者：
Kong, Xiangju [1 ]
Yan, Qingna [2 ]
Niu, Yucun [2 ]
Liu, Liyan [2 ]
机构：
[1] Harbin Med Univ, Affiliated Hosp 1, Dept Gynaecol, Harbin, Peoples R China
[2] Harbin Med Univ, Publ Hlth Coll, Dept Nutr & Food Hyg, 157 Baojian Rd, Harbin 150086, Peoples R China
来源：
BIOMEDICAL CHROMATOGRAPHY | 2022年 / 36卷 / 12期
关键词：
adult offspring; maternal folic acid supplementation; metabolomics; neural metabolism; proteomics; NEURAL-TUBE DEFECTS; INSULIN-RESISTANCE; BRAIN; DEFICIENCY; PREGNANCY; NEUROTRANSMITTER; NEURODEVELOPMENT; EXPRESSION; PREVENTION; SIGNATURE;
D O I：
10.1002/bmc.5490
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The onset of complex diseases at a later stage of life has been linked with maternal folic acid (FA) ingestion. However, little is known regarding the underlying molecular fingerprints of the offspring. We integrated proteomics-metabolomics profiles and analyzed the influence of maternal FA supplementation on the metabolism of adult offspring rats. Twenty pregnant female rats were randomly assigned to a FA supplementation (FolS group, 10 mg/kg FA) or control group (2 mg/kg FA respectively). Such an omics approach revealed that the dopaminergic synapse pathway, tricarboxylic acid cycle and neural development-related metabolites such as glutamic acid and gamma-aminobutyric acid were significantly up-regulated in the FolS group, whereas pyruvic acid, oxalic acid and adipic acid were reduced. Maternal FA supplementation can cause alterations of metabolites and protein in the offspring rats.
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页数：12
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