Exploring the theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexes

被引：32
作者：
Juergens, Sophie [1 ,2 ,3 ]
Scalcon, Valeria [4 ]
Estrada-Ortiz, Natalia [5 ]
Folda, Alessandra [4 ]
Tonolo, Federica [4 ]
Jandl, Christian [1 ,2 ]
Browne, Duncan L. [3 ]
Rigobello, Maria Pia [4 ]
Kuehn, Fritz E. [1 ,2 ]
Casini, Angela [3 ,5 ,6 ]
机构：
[1] Tech Univ Munich, Catalysis Res Ctr, Mol Catalysis, Lichtenbergstr 4, D-85747 Garching, Germany
[2] Tech Univ Munich, Dept Chem, Lichtenbergstr 4, D-85747 Garching, Germany
[3] Cardiff Univ, Sch Chem, Pk Pl, Cardiff CF10 3AT, S Glam, Wales
[4] Univ Padua, Dept Biomed Sci, Via Ugo Bassi 58-B, I-35131 Padua, Italy
[5] Univ Groningen, Dept Pharmacokinet Toxicol & Targeting, A Deusinglaan 1, NL-9713 AV Groningen, Netherlands
[6] Tech Univ Munich, Inst Adv Study, Lichtenbergstr 2A, D-85748 Garching, Germany
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2017年 / 25卷 / 20期
关键词：
Gold(III) complexes; Cyclometalation; Anticancer agents; Thioredoxin reductase; Thiols; TRANSITION-METAL-COMPLEXES; HETEROCYCLIC CARBENE COMPLEXES; ANTIPROLIFERATIVE PROPERTIES; THIOREDOXIN REDUCTASE; CYTOTOXIC PROPERTIES; ANTICANCER AGENTS; CHEMISTRY; GOLD; PURIFICATION; SYSTEM;
D O I：
10.1016/j.bmc.2017.08.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A family of cyclometalated Au(III) complexes featuring a tridentate C<^>N<^>C scaffold has been synthesized and characterized. Microwave assisted synthesis of the ligands has also been exploited and optimized. The biological properties of the thus formed compounds have been studied in cancer cells and demonstrate generally moderate antiproliferative effects. Initial mechanistic insights have also been gained on the gold complex [Au(C<^>N<^>C)(GluS)] (3), and support the idea that the thioredoxin system may be a target for this family of compounds together with other relevant intracellular thiol-containing molecules. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5452 / 5460
页数：9
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