Sample size and power calculation in comparing diagnostic accuracy of biomarkers with pooled assessments

被引：9

作者：

Liu, AY

Schisterman, EF

Teoh, E

机构：

[1] NICHHD, Div Epidemiol Stat & Prevent Res, Rockville, MD 20852 USA

[2] Univ Alabama Birmingham, Birmingham, AL USA

来源：

JOURNAL OF APPLIED STATISTICS | 2004年 / 31卷 / 01期

关键词：

area under the curve; diagnostic biomarkers; sensitivity; specificity; receiver operating characteristic curves;

D O I：

10.1080/0266476032000148948

中图分类号：

O21 [概率论与数理统计]; C8 [统计学];

学科分类号：

020208 ; 070103 ; 0714 ;

摘要：

When testing of a biomarker is costly, pooling of samples becomes a useful and efficient alternative (Faraggi et al., 2003). In this paper, we develop procedures for sample size and power calculations for planning a study comparing the accuracy of biomarkers in diagnosis of diseases with pooled samples. Explicit formulas are derived for several important pooling strategies. The effects of pooling samples on sample size and power of the test are also discussed.

引用

页码：49 / 59

页数：11

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