Intestinal clear cell sarcoma with melanocytic differentiation and extraskeletal myxoid chondrosarcoma rearrangement: Report of a case

被引:17
作者
Abdulkader, Ihab [1 ]
Cameselle-Teijeiro, Jose [1 ]
de Alava, Enrique [2 ]
Ruiz-Ponte, Clara [3 ]
Used-Aznar, Maria M. [4 ]
Forteza, Jeronimo [1 ]
机构
[1] Univ Santiago de Compostela, Hosp Clin Univ, Dept Pathol, SERGAS, Galicia, Spain
[2] Univ Salamanca, CSIC, Ctr Invest Canc, IBMCC, Santiago De Compostela, Galicia, Spain
[3] Hosp Clin Univ, USC, Grp Med Xen, Fdn Publ Galega Med Xen, Santiago De Compostela, Galicia, Spain
[4] Hosp Arquitecto Marcide, SERGAS, Dept Pathol, Ferrol, Galicia, Spain
关键词
clear cell sarcoma; FISH; translocation; small bowel;
D O I
10.1177/1066896907306841
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
A clear cell sarcoma-like tumor with osteoclast-like giant cells of the gastrointestinal tract without immunoexpression of CD117 was recently proposed as a new tumor entity In this article, a case of a 37-year-old man with a neoplasm of the jejunum composed of polygonal cells with clear to eosinophilic cytoplasm forming nests and fascicles is reported. Giant cells were not identified. Immunohistochemically, the tumor cells expressed strongly SIN protein, human melanoma black 45, platelet-derived growth factor receptor a, B-cell lymphoma 2, p53, and to a lesser extent vimentin, neuron-specific enolase, and epithelial membrane antigen. Mindbomb homolog-1 index was 35%. Immunoreactivity for CD34 and CD117 was negative. The fluorescence in situ hybridization analysis showed a translocation involving chromosome 22q12, the diagnostic hallmark of clear cell sarcoma of soft tissues. This case indicates a close histogenetic relationship with the recently reported clear cell sarcoma with osteoclast-like giant cells of the gastrointestinal tract, as well as with the clear cell sarcoma of soft tissues.
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页码:189 / 193
页数:5
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