Clinical course of COVID-19 infection in paediatric familial Mediterranean fever patients

被引:1
作者
Kaya Akca, Ummusen [1 ]
Sener, Seher [1 ]
Balik, Zeynep [1 ]
Gurlevik, Sibel [2 ]
Oygar, Pembe Derin [2 ]
Atalay, Erdal [1 ]
Cuceoglu, Muserref Kasap [1 ]
Basaran, Ozge [1 ]
Batu, Ezgi Deniz [1 ]
Teksam, Ozlem [3 ]
Bilginer, Yelda [1 ]
Ozsurekci, Yasemin [2 ]
Ozen, Seza [1 ]
机构
[1] Hacettepe Univ, Div Pediat Rheumatol, Dept Pediat, Fac Med, Ankara, Turkey
[2] Hacettepe Univ, Dept Pediat Infect Dis, Fac Med, Ankara, Turkey
[3] Hacettepe Univ, Div Emergency, Dept Pediat, Fac Med, Ankara, Turkey
关键词
Familial Mediterranean fever; children; coronavirus; COVID-19; infection; colchicine; COLCHICINE; DIAGNOSIS;
D O I
10.1093/mr/roab056
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective To evaluate the course of coronavirus-19 (COVID-19) infection in paediatric familial Mediterranean fever (FMF) patients and to investigate the risk factors for COVID-19 infection. Methods Medical records of 100 consecutive paediatric FMF patients and their COVID-19 infection status were evaluated. Age- and gender-matched control group consisted of 51 patients with positive results for severe acute respiratory syndrome coronavirus 2. Results Twenty-five of 100 paediatric FMF patients were detected to have COVID-19 infection. A history of contact with a COVID-19 case was present in similar to 95% of patients in both the FMF and control groups with COVID-19 infection. Asymptomatic infection was detected in two patients in the paediatric FMF group (8.0%) and 17 patients in the control group (33.3%) (P = .017). Mild disease was observed in 23 paediatric FMF patients (92.0%) and 28 control patients (54.9%) (P = .001), whereas moderate disease was present in only 6 control patients (11.7%) (0 vs 11.7%, P = .074). Severe or critical disease was not observed in any patients. Conclusion Paediatric FMF patients receiving colchicine had no moderate COVID-19 disease compared to the control group. We suggest that colchicine use may tune down the severity of the disease even if it does not prevent COVID-19 infection.
引用
收藏
页码:467 / 472
页数:6
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