Oleiferasaponin A2, a Novel Saponin from Camellia oleifera Abel. Seeds, Inhibits Lipid Accumulation of HepG2 Cells Through Regulating Fatty Acid Metabolism

被引：22
作者：
Di, Tai-Mei [1 ]
Yang, Shao-Lan [1 ]
Du, Feng-Yu [2 ]
Zhao, Lei [1 ]
Li, Xiao-Han [1 ]
Xia, Tao [3 ]
Zhang, Xin-Fu [1 ]
机构：
[1] Qingdao Agr Univ, Coll Hort, Qingdao 266109, Peoples R China
[2] Qingdao Agr Univ, Coll Chem & Pharm, Qingdao 266109, Peoples R China
[3] Anhui Agr Univ, State Key Lab Tea Plant Biol & Utilizat, Hefei 230036, Anhui, Peoples R China
来源：
MOLECULES | 2018年 / 23卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Camellia oleifera; triterpenoid saponin; oleiferasaponin A(2); hypolipidemic activity; fatty acid metabolism; TRITERPENE SAPONINS; ETHANOLIC EXTRACT; CYCLE ARREST; FLOWER BUDS; CAKE; ANTIOBESITY; ANTIOXIDANT; POMACE; PROLIFERATION; EXPRESSION;
D O I：
10.3390/molecules23123296
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new triterpenoid saponin, named oleiferasaponin A(2), was isolated and identified from Camellia oleifera defatted seeds. Oleiferasaponin A(2) exhibited anti-hyperlipidemic activity on HepG2 cell lines. Further study of the hypolipidemic mechanism showed that oleiferasaponin A(2) inhibited fatty acid synthesis by significantly down-regulating the expression of SREBP-1c, FAS and FAS protein, while dramatically promoting fatty acid -oxidation by up-regulating the expression of ACOX-1, CPT-1 and ACOX-1 protein. Our results demonstrate that the oleiferasaponin A(2) possesses potential medicinal value for hyperlipidemia treatment.
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页数：11
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