Oxysterols, but not cholesterol, inhibit human immunodeficiency virus replication in vitro

被引：30
作者：
Moog, C
Aubertin, AM
Kirn, A
Luu, B
机构：
[1] INSERM, U74, Inst Virol, F-67000 Strasbourg, France
[2] CNRS, ULP, Lab Chim Organ Subst Nat, F-67084 Strasbourg, France
来源：
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1998年 / 9卷 / 06期
关键词：
HIV; oxysterols; cholesterol; antiviral;
D O I：
10.1177/095632029800900605
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxysterols, oxygenated derivatives of cholesterol selected for their cytostatic activity and their inhibitory effect on cholesterol synthesis, have been investigated for their anti-human immunodeficiency virus (HIV) activity in vitro. The three oxysterols tested, 7 beta-hydroxycholesterol (7 beta-OHC), 25-hydroxycholesterol (25-OHC) and 7 beta,25-dihydroxycholesterol (7,25-OHC), inhibit viral replication at micromolar concentrations. The selectivity indexes for 7 beta-OHC and 25-OHC are quite modest (2 to 8) but reproducible; the dihydroxycholesterol 7,25-OHC exhibited antiviral properties at concentrations 13- to 25-fold lower than the highest concentration tested at which no toxicity was measurable. Oxysterols are naturally occurring compounds, and we speculate on their physiological relevance in HIV-infected individuals.
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收藏
页码：491 / 496
页数：6
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