For IRES trans-acting factors, it is all about location

被引：73

作者：

Lewis, S. M. ^{[1
]}

Holcik, M. ^{[1
]}

机构：

[1] Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, Ottawa, ON K1H 8L1, Canada

来源：

ONCOGENE | 2008年 / 27卷 / 08期

关键词：

translation regulation; RNA binding protein; subcellular localization; vincristine;

D O I：

10.1038/sj.onc.1210777

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The translation of many proteins involved in transcription, cell cycle progression, apoptosis and cell survival is mediated by internal ribosome entry sites ( IRESs) present within the 5'-untranslated regions ( 5'-UTRs) of their messenger RNA molecules ( mRNAs). Several recent reports now demonstrate that the proteins controlling IRES-dependent translation initiation are regulated by their subcellular localization.

引用

页码：1033 / 1035

页数：3

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