Diethyl Selenodiglycolate: An Eco-Friendly Synthetic Antioxidant with Potential Application to Inflammatory Disorders

被引：4

作者：

Pinatto-Botelho, Marcos F. ^{[1
,2
]}

da Silva, Railmara P. ^{[3
]}

Archilha, Marcos V. L. R. ^{[1
,2
]}

Giroldo, Lilian ^{[1
]}

Kuznetsov, Aleksey E. ^{[4
]}

Meotti, Flavia C. ^{[3
]}

dos Santos, Alcindo A. ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP, Brazil

[2] Univ Sao Paulo, SelenoLife, Ctr Inovacao Empreendedorismo & Tecnol CIETEC, IPEN, BR-05508000 Sao Paulo, SP, Brazil

[3] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo, SP, Brazil

[4] Univ Tecn Federico Santa Maria, Dept Chem, Av Santa Maria 6400, Santiago 7660251, Chile

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2020年 / 31卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

diethyl selenodiglycolate; antioxidant; inflammation; oxidative burst; hypochlorous acid; PEROXIDASE-LIKE ACTIVITY; HYPOCHLOROUS ACID; PROTEIN OXIDATION; SELENIUM; MYELOPEROXIDASE; ORGANOSELENIUM; EBSELEN; ANALOGS; SUPEROXIDE; MECHANISMS;

D O I：

10.21577/0103-5053.20200009

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study describes a single step. high yield and purity. ecofriendly and scalable procedure to prepare a selenium derivative (diethyl selenodiglycolate). Diethyl selenodiglycolate rapidly reduces hypochlorous acid (HOCl, second-order rate constant of 7 x 10(7) M-1 s(-1)) to generate its corresponding selenoxide. In activated HL-60 cells, diethyl selenodiglycolate selectively reacted with HOCl (half maximal inhibitory concentration (IC50) = 23.07 mu M) but not with superoxide anion radical or hydrogen peroxide without any cytotoxicity. These results show that this synthetically simple selenide reacts in a very efficient and specific way with the harmful pro-oxidant HOCl being a promising compound to be applied in oxidative inflammatory-related conditions.

引用

页码：1239 / 1248

页数：10

共 50 条

[41] Green and eco-friendly synthesis of silver nanoparticles by Quercus infectoria galls extract: thermal behavior, antibacterial, antioxidant and anticancer properties [J].

Khatamifar, Marzieh ;

Fatemi, S. Jamilaldin ;

Torkzadeh-Mahani, Masoud ;

Mohammadi, Meisam ;

Hassanshahian, Mehdi .

PARTICULATE SCIENCE AND TECHNOLOGY, 2022, 40 (03) :281-289

[42] Eco-friendly fabrication of Ag/Pt bimetallic nanoparticles from clove extract: Enhanced physicochemical properties and biomedical potential [J].

Hasan, Prince Mufti Ziaul ;

Sharma, Chanchal ;

Ansari, Sana ;

Ansari, Mohammad Shahnawaze ;

Alam, Mohd Gulfam ;

Satsangee, Soami P. .

INORGANIC CHEMISTRY COMMUNICATIONS, 2025, 174

[43] Synthesis of Eco-friendly Cobalt Nanoparticles Using Celosia argentea Plant Extract and Their Efficacy Studies as Antioxidant, Antibacterial, Hemolytic and Catalytical Agent [J].

Shahzadi, Tayyaba ;

Zaib, Maria ;

Riaz, Tauheeda ;

Shehzadi, Saba ;

Abbasi, Muhammad Athar ;

Shahid, Muhammad .

ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING, 2019, 44 (07) :6435-6444

[44] Synthesis of Eco-friendly Cobalt Nanoparticles Using Celosia argentea Plant Extract and Their Efficacy Studies as Antioxidant, Antibacterial, Hemolytic and Catalytical Agent [J].

Tayyaba Shahzadi ;

Maria Zaib ;

Tauheeda Riaz ;

Saba Shehzadi ;

Muhammad Athar Abbasi ;

Muhammad Shahid .

Arabian Journal for Science and Engineering, 2019, 44 :6435-6444

[45] Calcination-dependent microstructural and optical characteristics of eco-friendly synthesized ZnO nanoparticles and their implementation in analog memristor application [J].

Pham, Quan Phu ;

Nguyen, Quy Ngoc Le ;

Nguyen, Ngoc Hong ;

Doan, Uyen Tu Thi ;

Ung, Thuy Dieu Thi ;

Tran, Vinh Cao ;

Phan, Thang Bach ;

Pham, Anh Tuan Thanh ;

Pham, Ngoc Kim .

CERAMICS INTERNATIONAL, 2023, 49 (12) :20742-20755

[46] Selenium nanoparticles synthesized using an eco-friendly method: dye decolorization from aqueous solutions, cell viability, antioxidant, and antibacterial effectiveness [J].

Al Jahdaly, Badreah A. ;

Al-Radadi, Najlaa S. ;

Eldin, Ghada M. G. ;

Almahri, Albandary ;

Ahmed, M. K. ;

Shoueir, Kamel ;

Janowska, Izabela .

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, 2021, 11 :85-97

[47] Eco-friendly alternatives to synthetic fertilizers for maximizing peanut (Arachis hypogea L.) production under arid regions in Punjab, Pakistan [J].

Ijaz, Muhammad ;

Perveen, Sonia ;

Nawaz, Ahmad ;

Ul-Allah, Sami ;

Sattar, Abdul ;

Sher, Ahmad ;

Ahmad, Saeed ;

Nawaz, Farukh ;

Rasheed, Iqra .

JOURNAL OF PLANT NUTRITION, 2020, 43 (05) :762-772

[48] Potential biological active bacteriocin production by Bifidobacterium via eco-friendly, low-cost solid state fermentation principle [J].

Priyanka, Srinivasan ;

Namasivayam, S. Karthick Raja ;

Sudha, S. ;

Lavanya, Muthukrishnan ;

Abiraamavalli, Thirumal .

ENVIRONMENTAL QUALITY MANAGEMENT, 2024, 34 (01)

[49] Eco-friendly processing in enzymatic xylooligosaccharides production from corncob: Influence of pretreatment with sonocatalytic-synergistic Fenton reaction and its antioxidant potentials [J].

Kawee-ai, Arthitaya ;

Srisuwun, Aungkana ;

Tantiwa, Nidtaya ;

Nontaman, Wimada ;

Boonchuay, Pinpanit ;

Kuntiya, Ampin ;

Chaiyaso, Thanongsak ;

Seesuriyachan, Phisit .

ULTRASONICS SONOCHEMISTRY, 2016, 31 :184-192

[50] Eco-Friendly Procedure for Rendering the Antibacterial and Antioxidant of Cotton Fabrics via Phyto-Synthesized AgNPs With Malva sylvestris (MS) Natural Colorant [J].

Sadeghi-Kiakhani, Mousa ;

Tehrani-Bagha, Ali Reza ;

Miri, Fateme Sadat ;

Hashemi, Elaheh ;

Safi, Mahdi .

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 9 (09)

← 1 2 3 4 5 →