Detection of nano-confined DNA using surface-plasmon enhanced fluorescence

被引：5
|
作者：
Cloutier, SG [1 ]
Lazareck, AD
Xu, J
机构：
[1] Brown Univ, Dept Engn, Providence, RI 02912 USA
[2] Brown Univ, Dept Phys, Providence, RI 02912 USA
来源：
APPLIED PHYSICS LETTERS | 2006年 / 88卷 / 01期
关键词：
D O I：
10.1063/1.2161813
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
Surface-plasmon resonance (SPR)-induced enhanced fluorescence was used to detect the presence of fluorescent TOTO-1 bis-intercalated lambda-DNA complexes introduced into a periodic nanopore array. As we show, the proposed technique allows a high detection sensitivity by providing a strong fluorescence-signal efficiency from nano-confined fluorescent complexes. This novel platform could be used for sensing applications, or to detect and investigate the unique behaviors of nano-confined molecular systems. (c) 2006 American Institute of Physics.
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页数：3
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