Gen(om)e duplications in the evolution of early vertebrates

被引：361
作者：
Sidow, A
机构：
[1] Whitehead Institute, 9 Cambridge Center, Cambridge
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1996年 / 6卷 / 06期
关键词：
D O I：
10.1016/S0959-437X(96)80026-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Phylogenetic analyses and sequence surveys of developmental regulator gene families indicate that two large-scale gene duplications, most likely genome duplications, occurred in ancestors of vertebrates. Relaxed constraints allowed duplicated and thus redundant genes to diverge in a two stage mechanism. Neutral changes dominated at first but then positively selected regulatory changes evolved the novel and increasingly complex vertebrate developmental program.
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页码：715 / 722
页数：8
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