Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging

被引：67

作者：

Mieszawska, Aneta J. ^{[1
,2
]}

Gianella, Anita ^{[1
,2
]}

Cormode, David P. ^{[1
,2
]}

Zhao, Yiming ^{[3
]}

Meijerink, Andries ^{[3
]}

Langer, Robert ^{[4
]}

Farokhzad, Omid C. ^{[5
]}

Fayad, Zahi A. ^{[1
,2
]}

Mulder, Willem J. M. ^{[1
,2
]}

机构：

[1] Mt Sinai Sch Med, Translat & Mol Imaging Inst, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Imaging Sci Labs, New York, NY 10029 USA

[3] Univ Utrecht, NL-3508 TC Utrecht, Netherlands

[4] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[5] Brigham & Womens Hosp, Lab Nanomed & Biomat, Dept Anesthesiol, Boston, MA 02115 USA

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 47期

关键词：

GOLD NANOPARTICLES; QUANTUM DOTS; CELLS; DRUG; DELIVERY; SIZE;

D O I：

10.1039/c2cc32149a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and biodegradable and therefore have been extensively investigated as therapeutic carriers. Here, we engineered diagnostically active PLGA nanoparticles that incorporate high payloads of nanocrystals into their core for tunable bioimaging features. We accomplished this through esterification reactions of PLGA to generate polymers modified with nanocrystals. The PLGA nanoparticles formed from modified PLGA polymers that were functionalized with either gold nanocrystals or quantum dots exhibited favorable features for computed tomography and optical imaging, respectively.

引用

页码：5835 / 5837

页数：3

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