Protecting podocytes: how good do we need to be?

被引：3

作者：

Lemley, Kevin V. ^{[1
]}

机构：

[1] Childrens Hosp Los Angeles, Div Nephrol, Los Angeles, CA 90027 USA

来源：

KIDNEY INTERNATIONAL | 2012年 / 81卷 / 01期

关键词：

INJURY; GLOMERULOSCLEROSIS; PROGRESSION; SEVERITY; RATS;

D O I：

10.1038/ki.2011.329

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Progression of many glomerular diseases has been firmly tied to a loss of podocytes, followed by a deterioration of glomerular architectural stability eventuating in segmental, and ultimately global, sclerosis. Recent studies have begun to clarify the nature of the autonomous (disease-independent) aspects of this process, as well as to explore mechanistically the 'unreasonable effectiveness' of angiotensin blockade in slowing glomerular disease progression. Quantitative monitoring of podocyte loss (e. g., to assess therapy) remains a challenge. Kidney International (2012) 81, 9-11. doi:10.1038/ki.2011.329

引用

页码：9 / 11

页数：4

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