Effect of compound 11 g as a novel selective cox-2 inhibitor on movement disorders in a rat model of Parkinson's disease

Objective: To test the effect of selective COX-2 inhibitors compound 11 g on movement disorders of Parkinson's disease (PD). Methodology: In the study the rat left substantia nigra pars compacta (SNc) has been destroyed using electrical lesion (10 Sec; 1 mA DC) to generate PD model. Then 11 g (2, 4mg/kg) and celecoxib a well known and standard COX-2 inhibitor (4, 8mg/kg) have been administrated orally to parkinsonian rats. Then the rigidity and Locomotor activity of parkinsonian rats were evaluated. Results: Both selective COX-2 inhibitors decreased the rigidity and improved the locomotor activity of parkinsonian rats P<0.05 as compared to the control groups. Conclusions: Based on the results of the Locomotor activity and rigidity tests using parkinsonian rats, we found that compound 11 g had remarkable rigidity-improving effect.