Effect of compound 11 g as a novel selective cox-2 inhibitor on movement disorders in a rat model of Parkinson's disease

被引：0

作者：

Ardestani, Mehdi Shafiee ^{[1
]}

Moghaddam, Hadi Fathi ^{[2
]}

Saffari, Mostafa ^{[3
]}

机构：

[1] Univ Tehran Med Sci, Dept Med Chem & Radiopharm, Fac Pharm, Tehran, Iran

[2] Joundishapour Univ Med Sci, Sch Med & Phys Res Ctr, Dept Phys, Ahvaz, Iran

[3] Shahid Beheshti Univ Med Sci, Dept Pharmaceut, Fac Pharm, Tehran, Iran

来源：

PAKISTAN JOURNAL OF MEDICAL SCIENCES | 2008年 / 24卷 / 03期

关键词：

compound (11g); celecoxib; electrical lesion; Parkinson's disease; inflammation; cyclooxygenase-2;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To test the effect of selective COX-2 inhibitors compound 11 g on movement disorders of Parkinson's disease (PD). Methodology: In the study the rat left substantia nigra pars compacta (SNc) has been destroyed using electrical lesion (10 Sec; 1 mA DC) to generate PD model. Then 11 g (2, 4mg/kg) and celecoxib a well known and standard COX-2 inhibitor (4, 8mg/kg) have been administrated orally to parkinsonian rats. Then the rigidity and Locomotor activity of parkinsonian rats were evaluated. Results: Both selective COX-2 inhibitors decreased the rigidity and improved the locomotor activity of parkinsonian rats P<0.05 as compared to the control groups. Conclusions: Based on the results of the Locomotor activity and rigidity tests using parkinsonian rats, we found that compound 11 g had remarkable rigidity-improving effect.

引用

页码：436 / 441

页数：6

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