Prognostic Impact of Desmoplastic Reaction Evaluation for Intrahepatic Cholangiocarcinoma

被引：13

作者：

Kojima, Satoki ^{[1
]}

Hisaka, Toru ^{[1
]}

Midorikawa, Ryuta ^{[1
]}

Naito, Yoshiki ^{[2
]}

Akiba, Jun ^{[2
]}

Tanigawa, Masahiko ^{[3
]}

Yano, Hirohisa ^{[3
]}

Akagi, Yoshito ^{[1
]}

Okuda, Koji ^{[1
]}

机构：

[1] Kurume Univ, Dept Surg, Fac Med, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan

[2] Kurume Univ Hosp, Dept Diagnost Pathol, Kurume, Fukuoka, Japan

[3] Kurume Univ, Dept Pathol, Fac Med, Kurume, Fukuoka, Japan

来源：

ANTICANCER RESEARCH | 2020年 / 40卷 / 08期

关键词：

Desmoplastic reaction; intrahepatic cholangiocarcinoma; microenvironment; EPITHELIAL-MESENCHYMAL TRANSITION; RECURRENCE PATTERNS; MANAGEMENT; CATEGORIZATION; METASTASIS; RESECTION; CANCER;

D O I：

10.21873/anticanres.14476

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: The purpose of this study was to clarify the relationship between the desmoplastic reaction (DR) and clinicopathological features, and the prognosis using cases of resected intrahepatic cholangiocarcinoma (ICC). Patients and Methods: Out of 54 cases that were preoperatively diagnosed with ICC and underwent resection at our department, 47 patients were included in this study. All sections were prepared from resected specimens and were microscopically observed following H&E staining. Stroma were evaluated at the advancing edge of the cancer and stratified into three DR types: mature (DR1), intermediate (DR2), and immature (DR3). Results: DR was correlated to the serum levels of CA19-9, but not to the other tumor factors. In multivariate analysis, only DR and tumor size were determined as independent prognostic factors. Conclusion: Evaluation of DR for ICC may be useful for prognostic assessments.

引用

页码：4749 / 4754

页数：6

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