Infertility in a man with oligoasthenoteratozoospermia associated with nonrobertsonian translocation t(9;15)(p10;q10)

Objective: To analyze an unusual nonrobertsonian translocation t(9;15)(p10;q10) found in an infertile man with oligoasthenoteratozoospermia who had a normal phenotype. Design: Case report with a review of scientific literature. Setting: Academic research environment. Patient(s): Infertile man with oligoasthenoteratozoospermia but otherwise apparently healthy. Intervention(s): Peripheral blood lymphocytes were obtained for karyotyping, and metaphases were studied by the GBG fluorescence in situ hybridization (FISH) procedure. Main Outcome Measure(s): Physical examination, semen analysis, GBG banding, and FISH procedure. Result(s): The semen analysis revealed oligoasthenoteratozoospermia. The lymphocytic karyotype detected a translocation t(9; 15)(p10; q10), and FISH procedure showed that the derived chromosome had a chromosome 15 centromere. Conclusion(s): The association of unusual translocation with male factor infertility was described. To our knowledge no such association has been described previously in men whose clinical manifestation is only infertility. (Fertil Steril (R) 2006;86:1001.e7-9. (C) 2006 by American Society for Reproductive Medicine.)