Do cereal mixed-linked ß-glucans possess immune-modulating activities?

被引:30
作者
Rieder, Anne [2 ]
Samuelsen, Anne Berit [1 ]
机构
[1] Univ Oslo, Dept Pharmaceut Chem, Sch Pharm, N-0316 Oslo, Norway
[2] Norwegian Inst Food Fisheries & Aquaculture Res, As, Norway
关键词
Anti-cancer activity; Cereal ss-glucan; Immune-modulation; Structure-functional relationship; Uptake; OAT BETA-GLUCAN; IN-VITRO FERMENTATION; BINDING LECTIN SITE; FACTOR-KAPPA-B; DIETARY FIBER; PHYSICOCHEMICAL PROPERTIES; MODERATE EXERCISE; PLASMA-GLUCOSE; PRIMED STATE; BARLEY;
D O I
10.1002/mnfr.201100723
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
beta-glucans are known for their immune-modulating properties. However, the heterogeneity of these glucose polymers makes a distinction between the different sources and structures necessarya fact that has been little allowed for in the literature. We have focused on beta-glucans from cereals as they are already used as functional food ingredients due to their established cholesterol lowering effect. Cereal beta-glucans have shown in vitro activity on cytokine secretion, phagocytic activity and cytotoxicity of isolated immune cells, and activation of the complement system. Animal studies suggest a possible protective effect against an intestinal parasite, against bacterial infection, and a synergistic effect in antibody-dependent cellular cytotoxicity. Animal studies have shown activity of orally applied cereal beta-glucans indicating uptake or interaction with cells of the gastrointestinal tract. However, uptake is still debated, interaction with intestinal epithelial cells has been suggested but not clarified, and mechanisms of action remain largely unknown. So far, cereal beta-glucans have not shown immune modulation in the few conducted human studies and further studies are needed to clarify their effect.
引用
收藏
页码:536 / 547
页数:12
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