Li-cadherin is inversely correlated with Galectin-3 expression in gastric cancer

被引：35
作者：
Dong, Wei-Guo [1 ]
Yu, Qiong-Fang [1 ]
Xu, Yu [2 ]
Fan, Li-Fang [3 ]
机构：
[1] Wuhan Univ, Renmin Hosp, Dept Gastroenterol, Wuhan 430060, Peoples R China
[2] Wuhan Univ, Renmin Hosp, Dept Otolaryngol Head & Neck Surg, Wuhan 430060, Peoples R China
[3] Wuhan Univ, Sch Med, Dept Pathol, Wuhan 430060, Peoples R China
来源：
DIGESTIVE DISEASES AND SCIENCES | 2008年 / 53卷 / 07期
关键词：
gastric cancer; Li-cadherin; Galectin-3; immunohistochemistry; semiquantitative polymerase chain reaction;
D O I：
10.1007/s10620-007-0080-2
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The aims of this study were to examine the expressions of Li-cadherin and Galectin-3 in gastric cancer, and the correlation between Li-cadherin and Galectin-3 in gastric cancer was also analyzed. The present study investigated the expression level of Li-cadherin and Galectin-3 by immunohistochemistry and semiquantitative polymerase chain reaction (PCR), and correlated this with clinicopathologic parameters in 91 cases of gastric cancer. The correlation between expression levels of Li-cadherin and Galectin-3 was analyzed by Spearman correlation analysis. The expression level of Li-cadherin mRNA was correlated to differentiation and lymph node metastasis, and the expression level of Galectin-3 was related to TNM staging, differentiation and lymph node metastasis. On Spearman correlation analysis, a definitive negative correlation was found between the expression levels of Li-cadherin and Galectin-3 in gastric cancerous tissues. We postulate that interaction between Li-cadherin and Galectin-3 may play an important role in the development of gastric cancer.
引用
收藏
页码：1811 / 1817
页数：7
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