Giant magnetoimpedance biosensor for ferrogel detection: Model system to evaluate properties of natural tissue

被引:68
作者
Kurlyandskaya, G. V. [1 ,2 ]
Fernandez, E. [3 ]
Safronov, A. P. [2 ,4 ]
Svalov, A. V. [1 ,2 ]
Beketov, I. [4 ]
Beitia, A. Burgoa [1 ]
Garcia-Arribas, A. [1 ,3 ]
Blyakhman, F. A. [5 ]
机构
[1] Univ Pais Vasco UPV EHU, Dept Elect & Elect, Bilbao 48080, Spain
[2] Ural Fed Univ, Inst Nat Sci, Ekaterinburg 620000, Russia
[3] Univ Pais Vasco UPV EHU, BCMat, Bilbao 48080, Spain
[4] Inst Electrophys UD RAS, Ekaterinburg 620016, Russia
[5] Ural State Med Univ, Dept Biomed Phys & Engn, Ekaterinburg 620028, Russia
关键词
IRON-OXIDE NANOPOWDERS; MAGNETO-IMPEDANCE; SENSOR; CELLS;
D O I
10.1063/1.4921224
中图分类号
O59 [应用物理学];
学科分类号
摘要
Thin-film based magnetoimpedance (MI) sensors were used for quantitative determination of the concentration of magnetic nanoparticles (MNPs) in ferrogels. Ferrogels (model systems for biological tissue) were synthesized by radical polymerization of acrylamide in a stable aqueous suspension of gamma-Fe2O3 MNPs fabricated by laser target evaporation. MI [FeNi/Ti](3)/Cu/[Ti/FeNi](3)/Ti sensitive elements were prepared by sputtering. Thorough structural and magnetic studies of MNPs, ferrogels, and multilayered sensitive element insure the complete characterization of biosensor prototype. The MI response of the sensitive element was carefully evaluated in initial state and in the presence of ferrogels with different concentration of iron oxide MNPs from 0 to 2.44 wt. %, which produced systematic changes of the MI in a frequency span of 300 kHz to 400 MHz. (C) 2015 AIP Publishing LLC.
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页数:5
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