Vaccination with soluble headless hemagglutinin protects mice from challenge with divergent influenza viruses

被引：75
作者：
Wohlbold, Teddy John [1 ,2 ]
Nachbagauer, Raffael [1 ,3 ]
Margine, Irina [1 ,2 ]
Tan, Gene S. [1 ]
Hirsh, Ariana [1 ]
Krammer, Florian [1 ]
机构：
[1] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA
[2] Icahn Sch Med Mt Sinai, Grad Sch Biol Sci, New York, NY 10029 USA
[3] Univ Vienna, Fac Life Sci, Vienna, Austria
来源：
VACCINE | 2015年 / 33卷 / 29期
关键词：
Influenza virus; Headless hemagglutinin; Universal influenza virus vaccine; Heterosubtypic immunity; HA stalk; DEPENDENT CELLULAR CYTOTOXICITY; STALK ANTIBODIES; CONSTRUCTS PROTECT; INFECTION; STEM; IMMUNOGENS; CELLS; INDUCTION; RESPONSES; EFFICACY;
D O I：
10.1016/j.vaccine.2015.05.038
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Current influenza virus vaccines provide solid protection from infection with viruses that are well matched with the vaccine strains. However, they do not protect efficiently against drifted or shifted strains. We developed an antigen based on the conserved stalk domain of the influenza virus hemagglutinin and tested its efficacy as a vaccine in a mouse virus challenge model. Although the antigen lacked the correct conformation of the native stalk domain and was not recognized by a panel of neutralizing stalk-reactive antibodies, it did induce considerable protection against H1N1, H5N1 and H6N1 challenge strains. Protection was enhanced when mice had pre-existing immunity against the stalk domain. Since pre-existing immunity is also present in the human population, we hypothesize that a similar antigen could show efficacy in humans as well. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3314 / 3321
页数：8
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