In situ microemulsion synthesis of hydroxyapatite-MgFe2O4 nanocomposite as a magnetic drug delivery system

被引：109

作者：

Foroughi, Firoozeh ^{[1
]}

Hassanzadeh-Tabrizi, S. A. ^{[1
]}

Bigham, Ashkan ^{[2
]}

机构：

[1] Islamic Azad Univ, Najafabad Branch, Young Researchers & Elite Club, Najafabad, Iran

[2] Islamic Azad Univ, Adv Mat Res Ctr, Dept Mat Engn, Najafabad, Iran

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2016年 / 68卷

关键词：

Microemulsion synthesis; Hydroxyapatite; Magnesium ferrite; Drug delivery; Ibuprofen; SOL-GEL SYNTHESIS; CONTROLLED-RELEASE; CALCINATION TEMPERATURE; COMPOSITE-PARTICLES; NANOPARTICLES; MORPHOLOGY; CHEMISTRY; IBUPROFEN; REMOVAL; SIZE;

D O I：

10.1016/j.msec.2016.07.028

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

In this study, an innovative synthesis process has been developed to produce hydroxyapatite-magnesium ferrite (HA-MgFe2O4) nanocomposite. In addition, the effect of calcination temperature on drug delivery behavior of produced samples was investigated. HA-MgFe2O4 nanocomposite was prepared via one-step modified reverse microemulsion synthesis route. The resulting products were characterized by X-ray Diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM), and Brunauer-Emmett-Teller surface area analysis (BET). The calcined samples at 500 and 700 degrees C demonstrated mesoporous characteristics and large specific surface areas of 88 and 32 m(2)/g, respectively. TEM and VSM results showed that the nanocomposite calcined at 700 degrees C has core-shell morphology and a maximum saturation magnetization of 9.47 emu g(-1). (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：774 / 779

页数：6

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