Gene therapy mitochondrial diseases using human cytoplasts

被引：25

作者：

Kagawa, Y ^{[1
]}

Hayashi, JI ^{[1
]}

机构：

[1] UNIV TSUKUBA,INST BIOL SCI,IBARAKI,OSAKA 305,JAPAN

来源：

GENE THERAPY | 1997年 / 4卷 / 01期

关键词：

cytoplasts; cybrids; mitochondrial DNA; heteroplasmy; homoplasmy; stochastic segregation;

D O I：

10.1038/sj.gt.3300347

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial (mt) DNA is highly susceptible to mutation. A novel approach using cytoplasis essential for gene therapy of the diseases caused by these mutations, because of their non-Mendelian genetics. In this method, mtDNA is transferred into the mutant cells by forming cybrids and can complement the defect correctly and safely.

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收藏

页码：6 / 10

页数：5

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