Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts

被引：40
作者：
Hu, YS
Zhou, H
Myers, D
Quinn, JMW
Atkins, GJ
Ly, C
Gange, C
Kartsogiannis, V
Elliott, J
Kostakis, P
Zannettino, ACW
Cromer, B
McKinstry, WJ
Findlay, DM
Gillespie, MT
Ng, KW
机构：
[1] St Vincents Hosp, Dept Endocrinol & Diabet, Fitzroy, Vic 3065, Australia
[2] St Vincents Inst Med Res, Bone Joint & Canc Unit, Fitzroy, Vic 3065, Australia
[3] Univ Melbourne, Dept Physiol, Parkville, Vic 3052, Australia
[4] Univ Adelaide, Dept Orthopaed Surg & Trauma, Adelaide, SA, Australia
[5] Inst Med & Vet Sci, Div Haematol, Adelaide, SA 5000, Australia
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 01期
关键词：
osteoclasts; C-type lectin; natural killer cell receptors; natural killer gene complex; bone resorption;
D O I：
10.1359/JBMR.0301215
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Osteoclast inhibitory lectin (OCIL) is a newly recognized inhibitor of osteoclast formation. We identified a human homolog of OCIL and its gene, determined its regulation in human osteoblast cell lines, and established that it can inhibit murine and human osteoclast formation and resorption. OCIL shows promise as a new antiresorptive.
引用
收藏
页码：89 / 99
页数：11
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