Microglia in Alzheimer's Disease: A Target for Therapeutic Intervention

被引：86
作者：
Zhang, Guimei [1 ,2 ]
Wang, Zicheng [1 ,2 ]
Hu, Huiling [3 ]
Zhao, Meng [1 ,2 ]
Sun, Li [1 ,2 ]
机构：
[1] Jilin Univ, First Hosp Jilin Univ, Dept Neurol, Changchun, Peoples R China
[2] Jilin Univ, First Hosp Jilin Univ, Neurosci Ctr, Changchun, Peoples R China
[3] Qingdao Univ, Affiliated Hosp, Dept Intens Care Unit, Qingdao, Shandong, Peoples R China
来源：
FRONTIERS IN CELLULAR NEUROSCIENCE | 2021年 / 15卷
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; beta-amyloid; microglia; neuroinflammation; tau; RECEPTOR CLASS-B; MACROPHAGE SCAVENGER RECEPTOR; PLAQUE-ASSOCIATED MICROGLIA; PURINERGIC P2X(7) RECEPTOR; LOW-DENSITY-LIPOPROTEIN; NF-KAPPA-B; AMYLOID-BETA; MOUSE MODEL; NLRP3; INFLAMMASOME; TAU PATHOLOGY;
D O I：
10.3389/fncel.2021.749587
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alzheimer's disease (AD) is one of the most common types of age-related dementia worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary tangles, dysregulated microglia also play deleterious roles in the AD pathogenesis. Numerous studies have demonstrated that unbridled microglial activity induces a chronic neuroinflammatory environment, promotes beta-amyloid accumulation and tau pathology, and impairs microglia-associated mitophagy. Thus, targeting microglia may pave the way for new therapeutic interventions. This review provides a thorough overview of the pathophysiological role of the microglia in AD and illustrates the potential avenues for microglia-targeted therapies, including microglial modification, immunoreceptors, and anti-inflammatory drugs.
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页数：18
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