Metagenomics and the Human Virome in Asymptomatic Individuals

被引：97

作者：

Rascovan, Nicolas ^{[1
,2
]}

Duraisamy, Raja ^{[1
,2
]}

Desnues, Christelle ^{[1
,2
]}

机构：

[1] Aix Marseille Univ, Fac Med, F-13385 Marseille, France

[2] URMITE, INSERM 1095, CNRS 7278, UM63,IRD 198, F-13385 Marseille, France

来源：

ANNUAL REVIEW OF MICROBIOLOGY, VOL 70 | 2016年 / 70卷

关键词：

human virome; metagenomics; bacteriophages; eukaryotic viruses; STRANDED-DNA VIRUSES; VAGINAL LACTOBACILLUS PHAGES; HUMAN GUT VIROME; TT VIRUS; ELECTRON-MICROSCOPY; VIRAL METAGENOMICS; RESPIRATORY-TRACT; CYSTIC-FIBROSIS; BACTERIAL; BACTERIOPHAGE;

D O I：

10.1146/annurev-micro-102215-095431

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

High-throughput sequencing technologies have revolutionized how we think about viruses. Investigators can now go beyond pathogenic viruses and have access to the thousands of viruses that inhabit our bodies without causing clinical symptoms. By studying their interactions with each other, with other microbes, and with host genetics and immune systems, we can learn how they affect health and disease. This article reviews current knowledge of the composition and diversity of the human virome in physiologically healthy individuals. It focuses on recent results from metagenomics studies and discusses the contribution of bacteriophages and eukaryotic viruses to human health.

引用

页码：125 / 141

页数：17

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