Exercise Inhibits NLRP3 Inflammasome Activation in Obese Mice via the Anti-Inflammatory Effect of Meteorin-like

被引：65

作者：

Javaid, Hafiz Muhammad Ahmad ^{[1
]}

Sahar, Namood E. ^{[1
]}

ZhuGe, De-Li ^{[1
]}

Huh, Joo Young ^{[1
]}

机构：

[1] Chonnam Natl Univ, Coll Pharm, Gwangju 61186, South Korea

来源：

CELLS | 2021年 / 10卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

exercise; myokines; adipose tissue; NLRP3; inflammasome; METRNL; type; 2; diabetes; INSULIN-RESISTANCE; METABOLISM; KINASE; MACROPHAGES; REGULATORS; CASPASE-1; DISEASE; MUSCLE; AMPK;

D O I：

10.3390/cells10123480

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Obesity is associated with chronic low-grade inflammation. The benefits of exercise are partly attributed to its anti-inflammatory effect, but whether exercise can regulate NLRP3 inflammasome activation in obese adipose tissue remains unknown. Meteorin-like (METRNL), a recently discovered myokine, has been implicated in mediating the effect of exercise on metabolism. Herein, we examined the effect of exercise and METRNL on NLRP3 inflammasome activation. High-fat diet (HFD)-induced obese mice were subjected to treadmill exercise for 8 weeks. A subgroup of HFD mice was switched to normal chow with the exercise intervention. Exercise and diet attenuated weight gain, fat accumulation, and insulin resistance in obese mice. In addition, exercise downregulated gene and protein levels of inflammasome markers, including NLRP3 and caspase-1, in adipose tissue. In isolated bone marrow-derived macrophages, activation of NLRP3 inflammasome was suppressed in the exercise group, as confirmed by the downregulation of IL-1 beta and IL-18. Exercise significantly enhanced the expression of METRNL in various muscle depots, and further in vitro analysis revealed that recombinant METRNL treatment inhibited IL-1 beta secretion in macrophages. In conclusion, exercise exerts its anti-inflammatory action by suppressing adipose tissue NLRP3 inflammasome, and this is, in part, associated with METRNL induction in muscle and its anti-inflammatory effects in macrophages.

引用

页数：19

共 62 条

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