Identification of genetic markers for Mycobacterium pinnipedii through genome analysis

被引：9

作者：

Bigi, F ^{[1
]}

Garcia-Pelayo, MC

Nuñez-Garcia, J

Peralta, A

Caimi, KC

Golby, P

Hinds, J

Cataldi, A

Gordon, SV

Romano, MI

机构：

[1] INTA, CICVyA, Inst Biotechnol, RA-1712 Castelar, Argentina

[2] Vet Lab Agcy, Weybridge KT15 3NB, Surrey, England

[3] St George Hosp, Sch Med, Dept Cellular & Mol Med, Bacterial Microarray Grp, London SW17 0RE, England

来源：

FEMS MICROBIOLOGY LETTERS | 2005年 / 248卷 / 02期

基金：

英国惠康基金;

关键词：

Mycobacterium pinnipedii; Mycobacterium bovis; genomic; deletion;

D O I：

10.1016/j.femsle.2005.05.034

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Tuberculosis in seals is caused by Mycobacterium pinnipedii, a member of the Mycobacterium? tuberculosis complex. In this study, we evaluated the extent of genetic variability among Mycobacterium bovis and M. pinnipedii by microarray-based comparative genomics. We identified two deletions that are exclusive to M. pinnipedii: PiD1 that removes the orthologues of the M. tuberculosis genes Rv3530c and Rv3531c, and PiD2 that encompasses genes Rv1977 and Rv1978. Interestingly, a deletion overlapping the previously described RD2 region was identified in some isolates of Mycobacterium microti and further characterised. (c) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：147 / 152

页数：6

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