The Specificity of Nitroxyl Chemistry Is Unique Among Nitrogen Oxides in Biological Systems

被引：80

作者：

Flores-Santana, Wilmarie ^{[1
]}

Salmon, Debra J. ^{[2
]}

Donzelli, Sonia ^{[3
,4
,5
]}

Switzer, Christopher H. ^{[1
]}

Basudhar, Debashree ^{[1
,2
]}

Ridnour, Lisa ^{[1
]}

Cheng, Robert ^{[1
]}

Glynn, Sharon A. ^{[1
]}

Paolocci, Nazareno ^{[6
,7
]}

Fukuto, Jon M. ^{[8
]}

Miranda, Katrina M. ^{[2
]}

Wink, David A. ^{[1
]}

机构：

[1] NCI, Radiat Biol Branch, NIH, Bethesda, MD 20892 USA

[2] Univ Arizona, Dept Chem & Biochem, Tucson, AZ USA

[3] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, Hamburg, Germany

[4] Univ Med Ctr Hamburg Eppendorf, Dept Expt & Clin Pharmacol, Hamburg, Germany

[5] Univ Med Ctr Hamburg Eppendorf, Cardiovasc Res Ctr, Hamburg, Germany

[6] Johns Hopkins Med Inst, Baltimore, MD 21205 USA

[7] Univ Perugia, Sect Gen Pathol, Dept Clin Med, I-06100 Perugia, Italy

[8] Sonoma State Univ, Dept Chem, Rohnert Pk, CA 94928 USA

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2011年 / 14卷 / 09期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

HYDROXY-L-ARGININE; NO-CENTER-DOT; CARDIAC SARCOPLASMIC-RETICULUM; SOLUBLE GUANYLATE-CYCLASE; DETERRENT AGENT CYANAMIDE; NEUTRAL AQUEOUS-SOLUTION; PROTEIN S-NITROSOTHIOLS; CYSTEINE SULFINIC ACID; FREE NITRIC-OXIDE; ANGELIS SALT;

D O I：

10.1089/ars.2010.3841

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The importance of nitric oxide in mammalian physiology has been known for nearly 30 years. Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more recent. While there has been speculation as to the biosynthesis of HNO, its pharmacological benefits have been demonstrated in several pathophysiological settings such as cardiovascular disorders, cancer, and alcoholism. The chemical biology of HNO has been identified as related to, but unique from, that of its redox congener nitric oxide. A summary of these findings as well as a discussion of possible endogenous sources of HNO is presented in this review. Antioxid. Redox Signal. 14, 1659-1674.

引用

页码：1659 / 1674

页数：16

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