Towards Laser Driven Hadron Cancer Radiotherapy: A Review of Progress

被引：102

作者：

Ledingham, Ken W. D. ^{[1
,2
]}

Bolton, Paul R. ^{[3
]}

Shikazono, Naoya ^{[4
]}

Ma, C. -M. Charlie ^{[5
]}

机构：

[1] Univ Strathclyde, Dept Phys, SUPA, Glasgow G40NG, Lanark, Scotland

[2] Selcuk Univ, Dept Phys, Fac Sci, TR-42031 Konya, Turkey

[3] Univ Munich, Fac Phys, D-85748 Garching, Germany

[4] Japan Atom Energy Agcy, Kansai Photon Sci Inst, Kizugawa, Kyoto 6190215, Japan

[5] Fox Chase Canc Ctr, Dept Radiat Oncol, Philadelphia, PA 19111 USA

来源：

APPLIED SCIENCES-BASEL | 2014年 / 4卷 / 03期

关键词：

proton radiotherapy; accelerators; high power lasers; laser acceleration; laser driven radiation therapy; laser desorption ionization; laser assisted classification of healthy and cancerous tissue; laser medical application centres; ACCELERATED PROTON; ELECTRON-BEAM; RADIATION-THERAPY; ION-ACCELERATION; PARTICLE SELECTION; ULTRATHIN TARGETS; MASS-SPECTROMETRY; DOSE PROPERTIES; HIGH-INTENSITY; GENERATION;

D O I：

10.3390/app4030402

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It has been known for about sixty years that proton and heavy ion therapy is a very powerful radiation procedure for treating tumors. It has an innate ability to irradiate tumors with greater doses and spatial selectivity compared with electron and photon therapy and, hence, is a tissue sparing procedure. For more than twenty years, powerful lasers have generated high energy beams of protons and heavy ions and it has, therefore, frequently been speculated that lasers could be used as an alternative to radiofrequency (RF) accelerators to produce the particle beams necessary for cancer therapy. The present paper reviews the progress made towards laser driven hadron cancer therapy and what has still to be accomplished to realize its inherent enormous potential.

引用

页码：402 / 443

页数：42

共 137 条

[1] Relativistic Buneman instability in the laser breakout afterburner [J].

Albright, B. J. ;

Yin, L. ;

Bowers, Kevin J. ;

Hegelich, B. M. ;

Flippo, K. A. ;

Kwan, T. J. T. ;

Fernandez, J. C. .

PHYSICS OF PLASMAS, 2007, 14 (09)

[2] Accelerators for hadrontherapy: From Lawrence cyclotrons to linacs [J].

Amaldi, U. ;

Bonomi, R. ;

Braccini, S. ;

Crescenti, M. ;

Degiovanni, A. ;

Garlasche, M. ;

Garonna, A. ;

Magrin, G. ;

Mellace, C. ;

Pearce, P. ;

Pitta, G. ;

Puggioni, P. ;

Rosso, E. ;

Andres, S. Verdu ;

Wegner, R. ;

Weiss, M. ;

Zennaro, R. .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2010, 620 (2-3) :563-577

[3]

[Anonymous], FREE RADICAL INDUCED

[4] Survival of tumor cells after proton irradiation with ultra-high dose rates [J].

Auer, Susanne ;

Hable, Volker ;

Greubel, Christoph ;

Drexler, Guido A. ;

Schmid, Thomas E. ;

Belka, Claus ;

Dollinger, Guenther ;

Friedl, Anna A. .

RADIATION ONCOLOGY, 2011, 6

[5] Laser-driven generation of fast particles [J].

Badziak, J. .

OPTO-ELECTRONICS REVIEW, 2007, 15 (01) :1-12

[6] Identification of Biological Tissues by Rapid Evaporative Ionization Mass Spectrometry [J].

Balog, Julia ;

Szaniszlo, Tamas ;

Schaefer, Karl-Christian ;

Denes, Julia ;

Lopata, Antal ;

Godorhazy, Lajos ;

Szalay, Daniel ;

Balogh, Lajos ;

Sasi-Szabo, Laszlo ;

Toth, Mikos ;

Takats, Zoltan .

ANALYTICAL CHEMISTRY, 2010, 82 (17) :7343-7350

[7]

Bartal T, 2012, NAT PHYS, V8, P139, DOI [10.1038/nphys2153, 10.1038/NPHYS2153]

[8]

Berlin Y. A., 2008, RAD CHEM BASICS APPL

[9] On the small divergence of laser-driven ion beams from nanometer thick foils [J].

Bin, J. H. ;

Ma, W. J. ;

Allinger, K. ;

Wang, H. Y. ;

Kiefer, D. ;

Reinhardt, S. ;

Hilz, P. ;

Khrennikov, K. ;

Karsch, S. ;

Yan, X. Q. ;

Krausz, F. ;

Tajima, T. ;

Habs, D. ;

Schreiber, J. .

PHYSICS OF PLASMAS, 2013, 20 (07)

[10] A laser-driven nanosecond proton source for radiobiological studies [J].

Bin, Jianhui ;

Allinger, Klaus ;

Assmann, Walter ;

Dollinger, Guenther ;

Drexler, Guido A. ;

Friedl, Anna A. ;

Habs, Dieter ;

Hilz, Peter ;

Hoerlein, Rainer ;

Humble, Nicole ;

Karsch, Stefan ;

Khrennikov, Konstantin ;

Kiefer, Daniel ;

Krausz, Ferenc ;

Ma, Wenjun ;

Michalski, Doerte ;

Molls, Michael ;

Raith, Sebastian ;

Reinhardt, Sabine ;

Roeper, Barbara ;

Schmid, Thomas E. ;

Tajima, Toshiki ;

Wenz, Johannes ;

Zlobinskaya, Olga ;

Schreiber, Joerg ;

Wilkens, Jan J. .

APPLIED PHYSICS LETTERS, 2012, 101 (24)

← 1 2 3 4 5 6 7 8 9 10 →