Neural Correlates of Mild Behavioral Impairment: A Functional Brain Connectivity Study Using Resting-State Functional Magnetic Resonance Imaging

被引:26
作者
Matsuoka, Teruyuki [1 ]
Ueno, Daisuke [1 ]
Ismail, Zahinoor [2 ,3 ,4 ,5 ]
Rubinstein, Ellen [6 ]
Uchida, Hiroyuki [7 ]
Mimura, Masaru [7 ]
Narumoto, Jin [1 ]
机构
[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Psychiat, Kamigyo Ku, 465 Kajii Cho, Kyoto 6028566, Japan
[2] Univ Calgary, Hotchkiss Brain Inst, Dept Psychiat, Calgary, AB, Canada
[3] Univ Calgary, Hotchkiss Brain Inst, Dept Clin Neurosci, Calgary, AB, Canada
[4] Univ Calgary, Hotchkiss Brain Inst, Dept Community Hlth Sci, Calgary, AB, Canada
[5] Univ Calgary, OBrien Inst Publ Hlth, Calgary, AB, Canada
[6] North Dakota State Univ, Dept Sociol & Anthropol, Fargo, ND USA
[7] Keio Univ, Dept Neuropsychiat, Sch Med, Shinjuku Ku, Tokyo, Japan
关键词
Default mode network; fronto-parietal control network; functional magnetic resonance imaging; mild behavioral impairment; salience network; NEUROPSYCHIATRIC SYMPTOMS; COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; DEMENTIA; NETWORK; SCALE; NEURODEGENERATION; PREVALENCE; DEPRESSION; CONVERSION;
D O I
10.3233/JAD-210628
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Mild behavioral impairment (MBI) is associated with accelerated cognitive decline and greater risk of dementia. However, the neural correlates of MBI have not been completely elucidated. Objective: The study aimed to investigate the correlation between cognitively normal participants and participants with amnestic mild cognitive impairment (aMCI) using resting-state functional magnetic resonance imaging. Methods: The study included 30 cognitively normal participants and 13 participants with aMCI (20 men and 23 women; mean age, 76.9 years). The MBI was assessed using the MBI checklist (MBI-C). Region of interest (ROI)-to-ROI analysis was performed to examine the correlation between MBI-C scores and functional connectivity (FC) of the default mode network, salience network, and frontoparietal control network (FPCN). Age, Mini-Mental State Examination score, sex, and education were used as covariates. A p-value of 0.05, with false discovery rate correction, was considered significant. Results: A negative correlation was observed between the MBI-C total score and FC of the left posterior parietal cortex with the right middle frontal gyrus. A similar result was obtained for the MBI-C affective dysregulation domain score. Conclusion: FPCN dysfunction was detected as a neural correlate of MBI, especially in the affective dysregulation domain. This dysfunction may be associated with cognitive impairment in MBI and conversion of MBI to dementia; however, further longitudinal data are needed to examine this relationship.
引用
收藏
页码:1221 / 1231
页数:11
相关论文
共 53 条
[1]   Association of Alzheimer's genetic loci with mild behavioral impairment [J].
Andrews, Shea J. ;
Ismail, Zahinoor ;
Anstey, Kaarin J. ;
Mortby, Moyra .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2018, 177 (08) :727-735
[2]   Neuropsychiatric Symptoms in Alzheimer's Disease Are Related to Functional Connectivity Alterations in the Salience Network [J].
Balthazar, Marcio L. F. ;
Pereira, Fabricio R. S. ;
Lopes, Tatila M. ;
da Silva, Elvis L. ;
Coan, Ana Carolina ;
Campos, Brunno M. ;
Duncan, Niall W. ;
Stella, Florindo ;
Northoff, Georg ;
Damasceno, Benito P. ;
Cendes, Fernando .
HUMAN BRAIN MAPPING, 2014, 35 (04) :1237-1246
[3]   Neuroimaging correlates of neuropsychiatric symptoms in Alzheimer's disease: a review of 20 years of research [J].
Boublay, N. ;
Schott, A. M. ;
Krolak-Salmon, P. .
EUROPEAN JOURNAL OF NEUROLOGY, 2016, 23 (10) :1500-1509
[4]   Genetic risk for Alzheimer's disease, cognition, and mild behavioral impairment in healthy older adults [J].
Creese, Byron ;
Arathimos, Ryan ;
Brooker, Helen ;
Aarsland, Dag ;
Corbett, Anne ;
Lewis, Cathryn ;
Ballard, Clive ;
Ismail, Zahinoor .
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING, 2021, 13 (01)
[5]   Profile of mild behavioral impairment and factor structure of the Mild Behavioral Impairment Checklist in cognitively normal older adults [J].
Creese, Byron ;
Griffiths, Alys ;
Brooker, Helen ;
Corbett, Anne ;
Aarsland, Dag ;
Ballard, Clive ;
Ismail, Zahinoor .
INTERNATIONAL PSYCHOGERIATRICS, 2020, 32 (06) :705-717
[6]   Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults [J].
Creese, Byron ;
Brooker, Helen ;
Ismail, Zahinoor ;
Wesnes, Keith A. ;
Hampshire, Adam ;
Khan, Zunera ;
Megalogeni, Maria ;
Corbett, Anne ;
Aarsland, Dag ;
Ballard, Clive .
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2019, 27 (08) :823-834
[7]   A systematic review and meta-analysis of memory-guided attention: Frontal and parietal activation suggests involvement of fronto-parietal networks [J].
Fischer, Manda ;
Moscovitch, Morris ;
Alain, Claude .
WILEY INTERDISCIPLINARY REVIEWS-COGNITIVE SCIENCE, 2021, 12 (01)
[8]   MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198
[9]   Neural correlates of the impulse dyscontrol domain of mild behavioral impairment [J].
Gill, Sascha ;
Wang, Meng ;
Mouches, Pauline ;
Rajashekar, Deepthi ;
Sajobi, Tolulope ;
MacMaster, Frank P. ;
Smith, Eric E. ;
Forkert, Nils D. ;
Ismail, Zahinoor .
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2021, 36 (09) :1398-1406
[10]   Functional connectivity in the resting brain: A network analysis of the default mode hypothesis [J].
Greicius, MD ;
Krasnow, B ;
Reiss, AL ;
Menon, V .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (01) :253-258