Neural Correlates of Mild Behavioral Impairment: A Functional Brain Connectivity Study Using Resting-State Functional Magnetic Resonance Imaging

被引:23
作者
Matsuoka, Teruyuki [1 ]
Ueno, Daisuke [1 ]
Ismail, Zahinoor [2 ,3 ,4 ,5 ]
Rubinstein, Ellen [6 ]
Uchida, Hiroyuki [7 ]
Mimura, Masaru [7 ]
Narumoto, Jin [1 ]
机构
[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Psychiat, Kamigyo Ku, 465 Kajii Cho, Kyoto 6028566, Japan
[2] Univ Calgary, Hotchkiss Brain Inst, Dept Psychiat, Calgary, AB, Canada
[3] Univ Calgary, Hotchkiss Brain Inst, Dept Clin Neurosci, Calgary, AB, Canada
[4] Univ Calgary, Hotchkiss Brain Inst, Dept Community Hlth Sci, Calgary, AB, Canada
[5] Univ Calgary, OBrien Inst Publ Hlth, Calgary, AB, Canada
[6] North Dakota State Univ, Dept Sociol & Anthropol, Fargo, ND USA
[7] Keio Univ, Dept Neuropsychiat, Sch Med, Shinjuku Ku, Tokyo, Japan
关键词
Default mode network; fronto-parietal control network; functional magnetic resonance imaging; mild behavioral impairment; salience network; NEUROPSYCHIATRIC SYMPTOMS; COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; DEMENTIA; NETWORK; SCALE; NEURODEGENERATION; PREVALENCE; DEPRESSION; CONVERSION;
D O I
10.3233/JAD-210628
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Mild behavioral impairment (MBI) is associated with accelerated cognitive decline and greater risk of dementia. However, the neural correlates of MBI have not been completely elucidated. Objective: The study aimed to investigate the correlation between cognitively normal participants and participants with amnestic mild cognitive impairment (aMCI) using resting-state functional magnetic resonance imaging. Methods: The study included 30 cognitively normal participants and 13 participants with aMCI (20 men and 23 women; mean age, 76.9 years). The MBI was assessed using the MBI checklist (MBI-C). Region of interest (ROI)-to-ROI analysis was performed to examine the correlation between MBI-C scores and functional connectivity (FC) of the default mode network, salience network, and frontoparietal control network (FPCN). Age, Mini-Mental State Examination score, sex, and education were used as covariates. A p-value of 0.05, with false discovery rate correction, was considered significant. Results: A negative correlation was observed between the MBI-C total score and FC of the left posterior parietal cortex with the right middle frontal gyrus. A similar result was obtained for the MBI-C affective dysregulation domain score. Conclusion: FPCN dysfunction was detected as a neural correlate of MBI, especially in the affective dysregulation domain. This dysfunction may be associated with cognitive impairment in MBI and conversion of MBI to dementia; however, further longitudinal data are needed to examine this relationship.
引用
收藏
页码:1221 / 1231
页数:11
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