Multidrug-Resistant Bacterial Donor-Derived Infections in Solid Organ Transplantation

被引:37
作者
Lewis, Jessica D. [1 ]
Sifri, Costi D. [1 ]
机构
[1] Univ Virginia Hlth Syst, Div Infect Dis & Int Hlth, POB 800473, Charlottesville, VA 22908 USA
关键词
Donor-derived infections; Multidrug-resistant bacteria; Solid organ transplant; STAPHYLOCOCCUS-AUREUS; PSEUDOMONAS-AERUGINOSA; ESCHERICHIA-COLI; TRANSMISSION; CARBAPENEMASE; RECIPIENTS; PNEUMONIAE; SPREAD; ENTEROBACTERIACEAE; VIRUS;
D O I
10.1007/s11908-016-0526-9
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Although rare, donor-derived infections (DDIs) caused by multidrug-resistant (MDR) bacteria can have devastating consequences for organ transplant recipients. Recognition of MDR bacterial DDIs can be challenging, as MDR bacteria are prevalent in most hospitals and distinguishing their transmission through transplantation from other, more typical routes of acquisition are difficult. New technologies such as whole genome sequencing have recently proven to be a powerful advance in the investigation of MDR bacterial DDIs. Once recognized, the optimal treatment of MDR bacterial DDIs is not clear. Herein, we review the clinical manifestations, outcomes, and management of MDR bacterial DDIs, and identify areas of uncertainty toward which the transplant community should direct further research efforts.
引用
收藏
页数:7
相关论文
共 28 条
[1]   Transmission of Methicillin-Resistant Staphylococcus aureus via Deceased Donor Liver Transplantation Confirmed by Whole Genome Sequencing [J].
Altman, D. R. ;
Sebra, R. ;
Hand, J. ;
Attie, O. ;
Deikus, G. ;
Carpini, K. W. D. ;
Patel, G. ;
Rana, M. ;
Arvelakis, A. ;
Grewal, P. ;
Dutta, J. ;
Rose, H. ;
Shopsin, B. ;
Daefler, S. ;
Schadt, E. ;
Kasarskis, A. ;
van Bakel, H. ;
Bashir, A. ;
Huprikar, S. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 (11) :2640-2644
[2]   Outcomes of transplantation using organs from a donor infected with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae [J].
Ariza-Heredia, E. J. ;
Patel, R. ;
Blumberg, E. A. ;
Walker, R. C. ;
Lewis, R. ;
Evans, J. ;
Sankar, A. ;
Willliams, M. D. ;
Rogers, J. ;
Milano, C. ;
Razonable, R. R. .
TRANSPLANT INFECTIOUS DISEASE, 2012, 14 (03) :229-236
[3]   A New Clone Sweeps Clean: the Enigmatic Emergence of Escherichia coli Sequence Type 131 [J].
Banerjee, Ritu ;
Johnson, James R. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (09) :4997-5004
[4]   Better Tests, Better Care: Improved Diagnostics for Infectious Diseases [J].
Caliendo, Angela M. ;
Gilbert, David N. ;
Ginocchio, Christine C. ;
Hanson, Kimberly E. ;
May, Larissa ;
Quinn, Thomas C. ;
Tenover, Fred C. ;
Alland, David ;
Blaschke, Anne J. ;
Bonomo, Robert A. ;
Carroll, Karen C. ;
Ferraro, Mary Jane ;
Hirschhorn, Lisa R. ;
Joseph, W. Patrick ;
Karchmer, Tobi ;
MacIntyre, Ann T. ;
Reller, L. Barth ;
Jackson, Audrey F. .
CLINICAL INFECTIOUS DISEASES, 2013, 57 :S139-S170
[5]  
Chung W., 2010, Morbidity and Mortality Weekly Report, V59, P1642
[6]  
Coll P, 1997, J HEART LUNG TRANSPL, V16, P464
[7]   Transmission of lymphocytic choriomeningitis virus by organ transplantation. [J].
Fischer, Staci A. ;
Graham, Mary Beth ;
Kuehnert, Matthew J. ;
Kotton, Camille N. ;
Srinivasan, Arjun ;
Marty, Francisco M. ;
Comer, James A. ;
Guarner, Jeannette ;
Paddock, Christopher D. ;
DeMeo, Dawn L. ;
Shieh, Wun-Ju ;
Erickson, Bobbie R. ;
Bandy, Utpala ;
DeMaria, Alfred, Jr. ;
Davis, Jeffrey P. ;
Delmonico, Francis L. ;
Pavlin, Boris ;
Likos, Anna ;
Vincent, Martin J. ;
Sealy, Tara K. ;
Goldsmith, Cynthia S. ;
Jernigan, Daniel B. ;
Rollin, Pierre E. ;
Packard, Michelle M. ;
Patel, Mitesh ;
Rowland, Courtney ;
Helfand, Rita F. ;
Nichol, Stuart T. ;
Fishman, Jay A. ;
Ksiazek, Thomas ;
Zaki, Sherif R. .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (21) :2235-2249
[8]   Uniform Definitions for Donor-Derived Infectious Disease Transmissions in Solid Organ Transplantation [J].
Garzoni, Christian ;
Ison, Michael G. .
TRANSPLANTATION, 2011, 92 (12) :1297-1300
[9]   Cross-Infection of Solid Organ Transplant Recipients by a Multidrug-Resistant Klebsiella pneumoniae Isolate Producing the OXA-48 Carbapenemase, Likely Derived from a Multiorgan Donor [J].
Giani, Tommaso ;
Conte, Viola ;
Mandala, Salvatore ;
D'Andrea, Marco Maria ;
Luzzaro, Francesco ;
Conaldi, Pier Giulio ;
Grossi, Paolo ;
Rossolini, Gian Maria .
JOURNAL OF CLINICAL MICROBIOLOGY, 2014, 52 (07) :2702-2705
[10]   Organ transplantation from a donor colonized with a multidrug-resistant organism: a case report [J].
Goldberg, E. ;
Bishara, J. ;
Lev, S. ;
Singer, P. ;
Cohen, J. .
TRANSPLANT INFECTIOUS DISEASE, 2012, 14 (03) :296-299