Opsoclonus-myoclonus-ataxia syndrome associated with chikungunya and dengue virus co-infection

被引：15

作者：

do Rosario, Mateus Santana ^{[1
,2
]}

Giovanetti, Marta ^{[1
,3
]}

Pereira de Jesus, Pedro Antonio ^{[2
,4
]}

Farias, Daniel Santana ^{[2
]}

Faria, Nuno R. ^{[5
]}

de Lima, Clayton Pereira S. ^{[6
]}

da Silva, Sandro Patroca ^{[6
]}

Nunes, Marcio Roberto ^{[6
]}

Junior Alcantara, Luiz Carlos ^{[1
]}

de Siqueira, Isadora Cristina ^{[1
]}

机构：

[1] Fundacao Oswaldo Cruz, Minist Saude, Inst Goncalo Moniz, Salvador, BA, Brazil

[2] Hosp Geral Roberto Santos, Secretaria Estadual Saude Bahia, Salvador, BA, Brazil

[3] Univ Roma Tor Vergata, Rome, Italy

[4] Univ Fed Bahia, Fac Med, Salvador, BA, Brazil

[5] Univ Oxford, Dept Zool, Oxford, England

[6] Inst Evandro Chagas, Ctr Tecnol & Inovacao, Ananindeua, Para, Brazil

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2018年 / 75卷

关键词：

Opsoclonus; Chikungunya; Dengue; NEUROLOGICAL MANIFESTATIONS; INFECTION; DIAGNOSIS;

D O I：

10.1016/j.ijid.2018.07.019

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare neurological disorder characterized by irregular multidirectional eye movements, myoclonus, cerebellar ataxia, sleep disturbances, and cognitive dysfunction. Although most commonly related to paraneoplastic syndrome, this condition has occasionally been described following infectious illnesses. This article reports the first case of OMAS in association with chikungunya and dengue virus co-infection. The genetic analysis identified chikungunya virus of East/Central/South African genotype and dengue serotype 4 virus of genotype II. This report represents an unusual clinical syndrome associated with viral co-infection and reinforces the need for clinical vigilance with regard to neurological syndromes in the context of emergent arboviruses. (c) 2018 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

引用

页码：11 / 14

页数：4

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