Clinical and tear cytokine profiles after advanced surface ablation refractive surgery: A six-month follow-up

被引:20
作者
Gonzalez-Garcia, Maria J. [1 ,2 ]
Murillo, Giovanna M. [1 ,3 ]
Pinto-Fraga, Jose [1 ,4 ]
Garcia, Noelia [1 ,5 ]
Fernandez, Itziar [1 ,2 ]
Maldonado, Miguel J. [1 ]
Calonge, Margarita [1 ,2 ]
Enriquez-de-Salamanca, Amalia [1 ,2 ]
机构
[1] Univ Valladolid, IOBA Inst Appl Ophthalmobiol, Campus Miguel Delibes,Paseo Belen 17, E-47011 Valladolid, Spain
[2] CIBER BBN Biomed Res Networking Ctr Bioengn Bioma, Valladolid, Spain
[3] Caja Salud CORDES, La Paz, Bolivia
[4] European Univ Miguel de Cervantes, Dept Hlth Sci, I HeALTH, Valladolid, Spain
[5] Clin Baviera, Valladolid, Spain
关键词
Advanced surface ablation; Refractive surgery; Ocular surface inflammation; Cytokines; Dry eye disease; IN-SITU KERATOMILEUSIS; DRY EYE DISEASE; WOUND-HEALING RESPONSE; CONTACT-LENS; PHOTOREFRACTIVE KERATECTOMY; CORNEAL INNERVATION; INFLAMMATORY RESPONSE; LASIK; SENSITIVITY; MYOPIA;
D O I
10.1016/j.exer.2020.107976
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Neuropathic dry eye is one of the most frequently seen complications after corneal refractive surgery, however, its incidence decreases in a significant manner along the first six months postoperative, reaching between 10 and 45% incidence. However, little is known on the inflammatory status of the ocular surface during this recovery process. We aim to analyze the clinical and tear molecule concentration changes along six months after advanced surface ablation for myopia correction, in a prospective study including 18 eyes of 18 subjects who bilaterally underwent advanced surface ablation corneal refractive surgery. Clinical variables (uncorrected distance visual acuity, symptoms, conjunctival hyperemia, tear osmolarity, tear stability, corneal fluorescein staining, conjunctival lissamine staining, Schirmer test, and corneal esthesiometry) and a panel of 23 pro and anti-inflammatory cytokines/chemokines concentration in tears preoperatively and at 1, 3 and 6 months postoperatively were evaluated. We found that uncorrected distance visual acuity improved significantly from baseline at 1-month visit, symptoms improved and tear osmolarity decreased significantly from baseline at 3-month visit and there was a decrease in mechanical corneal threshold between 1-month and 3- and 6-month visits. Regarding tear molecules, IL-4, IL-5, IL-6, IL-13, IL-17A, and IFN-gamma tear levels were significantly increased at all the three visits, compared to preoperative levels at V0; IL-2 and VEGF were also significantly increased at 1-month and 6-month visits, but not at 3-month visit, whereas IL-9 IL-10 and IL-12 were only significantly increased at 6-month visit. Although we found that there is a recovery in clinical variables at 6 months postoperatively (i.e. neuropathic dry eye was not developed in the sample), ocular surface homeostasis is not completely restored, as it can be seen by the changes in concentration of some pro and anti-inflammatory molecules measured in tears.
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页数:11
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