Sialic Acid Mimetics to Target the Sialic Acid-Siglec Axis

被引：120

作者：

Bull, Christian ^{[1
]}

Heise, Torben ^{[2
]}

Adema, Gosse J. ^{[1
]}

Boltje, Thomas J. ^{[2
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Radboud Inst Mol Life Sci, Dept Tumor Immunol, Geert Grootepl 28, NL-6525 GA Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Inst Mol & Mat, Cluster Mol Chem, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2016年 / 41卷 / 06期

关键词：

INNATE IMMUNE-RESPONSE; HIGH-AFFINITY LIGAND; B-CELL TOLERANCE; INHIBITORY RECEPTOR; MODIFIED SIALOSIDES; PAIRED RECEPTORS; COMMON VARIANTS; MAG ANTAGONISTS; CD22; BINDING;

D O I：

10.1016/j.tibs.2016.03.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sialic acid sugars are vital regulators of the immune system through binding to immunosuppressive sialic acid-binding immunoglobulin-like lectin (Siglec) receptors on immune cells. Aberrant sialic acid-Siglec interactions are associated with an increasing number of pathologies including infection, autoimmunity, and cancer. Therefore, the sialic acid-Siglec axis is an emerging target to prevent or affect the course of several diseases. Chemical modifications of the natural sialic acid ligands have led to sialic acid mimetics (SAMs) with improved binding affinity and selectivity towards Siglecs. Recent progress in glycobiotechnology allows the presentation of these SAMs on nanoparticles, polymers, and living cells via bioorthogonal synthesis. These developments now enable the detailed study of the sialic acid-Siglec axis including its therapeutic potential as an immune modulator.

引用

页码：519 / 531

页数：13

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