Correlation analysis of two serum-specific Immunoglobulin E test systems and skin-prick test in allergic rhinitis patients from northeast China

被引:21
作者
Jiang, Xiao-Dan [1 ]
Li, Guang-Yu [1 ]
Dong, Zhen [1 ]
Zhu, Dong-Dong [1 ]
机构
[1] Jilin Univ, China Japan Union Hosp, Dept Otorhinolaryngol Head & Neck Surg, Changchun 130033, Peoples R China
关键词
IGE; IMMUNOASSAYS; DIAGNOSIS; IMMUNOCAP; PANEL;
D O I
10.2500/ajra.2011.25.3572
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background: Skin-prick testing (SPT) is the most common screening method for allergy evaluation. The detection of serum-specific immunoglobulin E (sIgE) is also commonly used. The sensitivity and specificity of these testing methods may vary due to type of causative allergen and type of allergic manifestation. The purpose of this study was to evaluate the correlation between two methods of measuring sIgE (AllergyScreen [Mediwiss Analytic GmbH, Moers, Germany] and ImmunoCAP [Pharmacia, Uppsala, Sweden]) and SPT for the diagnosis of allergic rhinitis (AR). Methods: All 216 patients who were referred to the allergist for suspected AR from June to October 2009 had SPT and the two serological tests. One hundred fifty-eight patients had a positive clinical history and a related positive SPT. The SPT was used as reference standard, and we selected three allergens (Dermatophagoides pteronyssinus, mugwort, and ragweed), which were common in fall in northeast China, to analyze the correlation of the two serum tests and SPT. Results: Compared with the SPT, the diagnostic indexes (accuracy, sensitivity and specificity) of the AllergyScreen system and the ImmunoCAP system were 0.819 versus 0.810, 0.780 versus 0.872, and 0.862 versus 0.741, respectively. The accuracy was similar between the two systems (p > 0.05). The ImmunoCAP system method had a higher sensitivity (p < 0.01). The AllergyScreen system had a higher specificity (p < 0.01). Conclusion: These data support that the AllergyScreen system and ImmunoCAP system can identify potentially significant allergens in the diagnosis of AR in patients from northeastern China. (Am J Rhinol Allergy 25, 116-119, 2011; doi: 10.2500/ajra.2011.25.3572)
引用
收藏
页码:116 / 119
页数:4
相关论文
共 20 条
[1]   Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen) [J].
Bousquet, J. ;
Khaltaev, N. ;
Cruz, A. A. ;
Denburg, J. ;
Fokkens, W. J. ;
Togias, A. ;
Zuberbier, T. ;
Baena-Cagnani, C. E. ;
Canonica, G. W. ;
van Weel, C. ;
Agache, I. ;
Ait-Khaled, N. ;
Bachert, C. ;
Blaiss, M. S. ;
Bonini, S. ;
Boulet, L. -P. ;
Bousquet, P. -J. ;
Camargos, P. ;
Carlsen, K. -H. ;
Chen, Y. ;
Custovic, A. ;
Dahl, R. ;
Demoly, P. ;
Douagui, H. ;
Durham, S. R. ;
van Wijk, R. Gerth ;
Kalayci, O. ;
Kaliner, M. A. ;
Kim, Y. -Y. ;
Kowalski, M. L. ;
Kuna, P. ;
Le, L. T. T. ;
Lemiere, C. ;
Li, J. ;
Lockey, R. F. ;
Mavale-Manuel, S. ;
Meltzer, E. O. ;
Mohammad, Y. ;
Mullol, J. ;
Naclerio, R. ;
Hehir, R. E. O. ;
Ohta, K. ;
Ouedraogo, S. ;
Palkonen, S. ;
Papadopoulos, N. ;
Passalacqua, G. ;
Pawankar, R. ;
Popov, T. A. ;
Rabe, K. F. ;
Rosado-Pinto, J. .
ALLERGY, 2008, 63 :8-+
[2]   Allergic rhinitis and its impact on asthma [J].
Bousquet, J ;
van Cauwenberge, P ;
Khaltaev, N ;
Ait-Khaled, N ;
Annesi-Maesano, I ;
Bachert, C ;
Baena-Cagnani, C ;
Bateman, E ;
Bonini, S ;
Canonica, GW ;
Carlsen, KH ;
Demoly, P ;
Durham, SR ;
Enarson, D ;
Fokkens, WJ ;
van Wijk, RG ;
Howarth, P ;
Ivanova, NA ;
Kemp, JP ;
Klossek, JM ;
Lockey, RF ;
Lund, V ;
Mackay, I ;
Malling, HJ ;
Meltzer, EO ;
Mygind, N ;
Okunda, M ;
Pawankar, R ;
Price, D ;
Scadding, GK ;
Simons, FER ;
Szczeklik, A ;
Valovirta, E ;
Vignola, AM ;
Wang, DY ;
Warner, JO ;
Weiss, KB .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (05) :S147-S334
[3]   Comparison of serum-specific IgE (ImmunoCAP) and skin-prick test results for 53 inhalant allergens in patients with chronic rhinitis [J].
Calabria, Christopher W. ;
Dietrich, Jeffrey ;
Hagan, Larry .
ALLERGY AND ASTHMA PROCEEDINGS, 2009, 30 (04) :386-396
[4]  
Costongs GMPJ, 1997, EUR J CLIN CHEM CLIN, V35, P885
[5]   Skin testing and immunoassays for allergen-specific IgE [J].
Dolen, WK .
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2001, 21 (2-3) :229-239
[6]   POSITION PAPER - ALLERGEN STANDARDIZATION AND SKIN-TESTS [J].
DREBORG, S ;
FREW, A .
ALLERGY, 1993, 48 (14) :49-82
[7]   EVALUATION OF A CAPSULATED HYDROPHILIC CARRIER POLYMER (THE IMMUNOCAP) FOR MEASUREMENT OF SPECIFIC IGE ANTIBODIES [J].
EWAN, PW ;
COOTE, D .
ALLERGY, 1990, 45 (01) :22-29
[8]   Diagnostic and analytical performance of a screening panel for allergy [J].
Herzum, I ;
Blümer, N ;
Kersten, W ;
Renz, H .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2005, 43 (09) :963-966
[9]  
Kersten W, 2002, ALLERGOLOGIE, V25, P203
[10]   Allergic rhinitis with negative skin tests: Does it exist? [J].
Khan, David A. .
ALLERGY AND ASTHMA PROCEEDINGS, 2009, 30 (05) :465-469