Bioprospecting for antituberculosis leads from microbial metabolites

被引：51

作者：

Ashforth, Elizabeth Jane ^{[1
]}

Fu, Chengzhang ^{[1
,3
]}

Liu, Xiangyang ^{[1
]}

Dai, Huanqin ^{[1
]}

Song, Fuhang ^{[1
]}

Guo, Hui ^{[1
,3
]}

Zhang, Lixin ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China

[2] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

来源：

NATURAL PRODUCT REPORTS | 2010年 / 27卷 / 11期

基金：

中国国家自然科学基金;

关键词：

MYCOBACTERIUM-TUBERCULOSIS; NATURAL-PRODUCTS; RNA-POLYMERASE; GENE CLUSTERS; LC-NMR; ANTIBIOTICS; BACTERIAL; DISCOVERY; DIVERSITY; MEMBRANE;

D O I：

10.1039/c0np00008f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microbial metabolites have been an important source of tuberculosis (TB) therapeutics, but the last truly novel drug that was approved for the treatment of TB was discovered 40 years ago. In light of the growing threat of multi-drug resistance, recent advances have been made to accelerate the discovery rate of novel TB drugs including diversifying strategies for environmental strains, and high-throughput screening assays. This review will discuss the approaches used in biodiversity- and taxonomy-guided microbial natural product library construction, specific cell-based and target-based high-throughput screening assays and early-stage dereplication processes by liquid chromatography-mass spectrometry (LC-MS). New antituberculosis natural products that have been recently discovered are highlighted.

引用

页码：1709 / 1719

页数：11

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