Electrochemical detection of serotonin: A new approach

被引:63
作者
Khoshnevisan, Kamyar [1 ,2 ]
Honarvarfard, Elham [3 ]
Torabi, Farzad [4 ,5 ]
Maleki, Hassan [6 ]
Baharifar, Hadi [7 ]
Faridbod, Farnoush [6 ]
Larijani, Bagher [2 ]
Khorramizadeh, Mohammad Reza [1 ,2 ]
机构
[1] Univ Tehran Med Sci, Biosensor Res Ctr, Endocrinol & Metab Mol Cellular Sci Inst, Tehran, Iran
[2] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran
[3] Clarkson Univ, Dept Chem & Biomol Sci, Potsdam, NY 13699 USA
[4] Univ Tehran, Coll Sci, Sch Chem, Tehran, Iran
[5] Univ Tehran, Coll Sci, Ctr Excellence Electrochem, Sch Chem, Tehran, Iran
[6] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Med Nanotechnol, Tehran, Iran
[7] Islamic Azad Univ, Appl Biophoton Res Ctr, Dept Med Nanotechnol, Sci & Res Branch, Tehran, Iran
关键词
Serotonin; Electrochemical sensing; Biomarker; Conductive polymers; Glassy carbon electrode; Polymer modification; PLATELET-POOR PLASMA; ASCORBIC-ACID; VOLTAMMETRIC DETERMINATION; LIQUID-CHROMATOGRAPHY; CEREBROSPINAL-FLUID; MODIFIED ELECTRODE; CARBON ELECTRODES; SENSOR; DOPAMINE; GRAPHENE;
D O I
10.1016/j.cca.2019.10.028
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter which plays a significant role in various functions in the body, such as appetite, emotions, and autonomic functions. It is well known that biomarker 5-HT levels can be correlated to several diseases and disorders such as depression, anxiety, irritable bowel, and sleep trouble. Among various methods for detecting the 5-HT biomarker, electrochemical techniques have attracted great interest due to their low cost and ease of operation. However, sensitive and precise electrochemical detection of 5-HT levels is not possible using bare electrodes, thus requiring electrode modification. The present review aims to describe the different electroanalytical methods for 5-HT detection using various surface-modified electrodes such as glassy carbon, carbon fiber, diamond, graphite, and metal electrodes modified with conductive polymers. Perspectives and the modification of electrode surface using applied polymers for 5-HT detection have also been presented.
引用
收藏
页码:112 / 119
页数:8
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