Takayasu myocarditis mediated by cytotoxic T lymphocytes

被引：33

作者：

Takeda, N ^{[1
]}

Takahashi, T ^{[1
]}

Seko, Y ^{[1
]}

Maemura, K ^{[1
]}

Nakasone, H ^{[1
]}

Sakamoto, K ^{[1
]}

Hirata, Y ^{[1
]}

Nagai, R ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan

来源：

INTERNAL MEDICINE | 2005年 / 44卷 / 03期

关键词：

Takayasu arteritis; gamma delta T lymphocytes; immunosuppressive therapy; hypothalamic hypopituitarism;

D O I：

10.2169/internalmedicine.44.256

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 15-year-old Japanese man was referred for evaluation of heart failure. Conventional heart failure therapy had little effect, and severe left ventricular dysfunction as well as elevated erythrocyte sedimentation rate persisted. Magnetic resonance angiography showed aortic dilatation with wall thickening characteristic of Takayasu's arteritis. An endomyocardial biopsy specimen revealed infiltration of natural killer cells and gamma delta T lymphocytes, which play major roles in vascular injury of Takayasu's arteritis. Prednisolone administration provided great benefits to cardiac function. These findings suggest that autoimmune cytotoxic mechanisms similar to those in arterial tissue may contribute to cardiac impairment in Takayasu's arteritis.

引用

页码：256 / 260

页数：5

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