Difluorohomologation of Ketones

被引：67

作者：

Kosobokov, Mikhail D. ^{[1
]}

Levin, Vitalij V. ^{[1
]}

Struchkova, Marina I. ^{[1
]}

Dilman, Alexander D. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

FREE CLICK CHEMISTRY; ORGANOZINC REAGENTS; ALPHA-ARYLATION; ARYL BROMIDES; CF2; GROUP; ALPHA; ALPHA-DIFLUOROKETONES; DIFLUOROCARBENE; ROUTE; ACIDS; DIFLUORINATION;

D O I：

10.1021/acs.orglett.5b00097

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for the homologation of ketones with the CF2 fragment is described. The reaction involves silylation, room-temperature difluorocyclopropanation of silyl enol ethers, and selective ring opening of cyclopropanes under acidic conditions. The whole three-step sequence is conveniently performed in a one-pot mode.

引用

页码：760 / 763

页数：4

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