Difluorohomologation of Ketones

被引:67
作者
Kosobokov, Mikhail D. [1 ]
Levin, Vitalij V. [1 ]
Struchkova, Marina I. [1 ]
Dilman, Alexander D. [1 ]
机构
[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia
基金
俄罗斯基础研究基金会;
关键词
FREE CLICK CHEMISTRY; ORGANOZINC REAGENTS; ALPHA-ARYLATION; ARYL BROMIDES; CF2; GROUP; ALPHA; ALPHA-DIFLUOROKETONES; DIFLUOROCARBENE; ROUTE; ACIDS; DIFLUORINATION;
D O I
10.1021/acs.orglett.5b00097
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A method for the homologation of ketones with the CF2 fragment is described. The reaction involves silylation, room-temperature difluorocyclopropanation of silyl enol ethers, and selective ring opening of cyclopropanes under acidic conditions. The whole three-step sequence is conveniently performed in a one-pot mode.
引用
收藏
页码:760 / 763
页数:4
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