Medical and Surgical Obesity Treatments and Atherosclerosis: Mechanisms beyond Typical Risk Factors

被引:7
作者
Bostrom, John A. [1 ]
Mottel, Beth [1 ]
Heffron, Sean P. [1 ]
机构
[1] NYU, Dept Med, Cardiovasc Res Ctr, Ctr Prevent Cardiovasc Dis,Leon H Charney Div Car, 550 1St Ave, New York, NY 10016 USA
关键词
Obesity; GLP-1; agonists; Bariatric surgery; Atherosclerosis; Cardiovascular outcomes; GLUCAGON-LIKE PEPTIDE-1; CHOLESTEROL EFFLUX CAPACITY; CORONARY-HEART-DISEASE; Y GASTRIC BYPASS; BARIATRIC SURGERY; CARDIOVASCULAR OUTCOMES; ENDOTHELIAL FUNCTION; GUT MICROBIOTA; WEIGHT-LOSS; PLAQUE STABILITY;
D O I
10.1007/s11883-021-00961-0
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Purpose of review This study aims to discuss the mechanisms by which GLP-1 agonists and bariatric surgery improve cardiovascular outcomes in severely obese patients. Recent findings Recent studies have demonstrated that both GLP-1 agonist use and bariatric surgery reduce adverse cardiovascular outcomes. Improvements in traditional atherosclerosis risk factors in association with weight loss likely contribute, but weight loss-independent mechanisms are also suggested to have roles. We review the clinical and preclinical evidence base for cardiovascular benefit of LP-1 agonists and bariatric surgery beyond traditional risk factors, including improvements in endothelial function, direct impacts on atherosclerotic plaques, and anti-inflammatory effects.
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页数:11
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