JAK1 Takes a FERM Hold of Type II Cytokine Receptors

被引：6

作者：

Babon, Jeffrey J. ^{[1
]}

Liau, Nicholas P. D. ^{[1
]}

Kershaw, Nadia J. ^{[1
]}

机构：

[1] Univ Melbourne, Walter & Eliza Hall Inst Med Res, Dept Med Biol, Parkville, Vic 3052, Australia

来源：

STRUCTURE | 2016年 / 24卷 / 06期

关键词：

STRUCTURAL BASIS; RECOGNITION;

D O I：

10.1016/j.str.2016.05.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Janus kinases (JAKs) initiate the intracellular signaling cascade triggered by exposure of cells to cytokines and interferons. In order to achieve this, JAKs are bound to the intracellular domain of specific cytokine receptors immediately adjacent to the cell membrane. In this issue of Structure, Ferrao et al. (2016) provide structural details of such an interaction and in doing so, identify for the first time the motif used by type II cytokine receptors to recruit JAK1.

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收藏

页码：840 / 842

页数：4

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